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Attention Score in Context
| Title |
The impact of social isolation on HPA axis function, anxiety-like behaviors, and ethanol drinking
|
|---|---|
| Published in |
Frontiers in Integrative Neuroscience, January 2014
|
| DOI | 10.3389/fnint.2013.00102 |
| Pubmed ID | |
| Authors |
Tracy R. Butler, Olusegun J. Ariwodola, Jeffrey L. Weiner |
| Abstract |
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is often observed in alcoholics and humans subjected to early life stress, and animal models of ethanol (EtOH) dependence. We examined HPA axis function in a rodent model of early life stress that engenders increases in behavioral and neurobiological risk factors of alcoholism. Long-Evans male rats were group housed (GH) or socially isolated (SI) for 6 weeks during adolescence. We examined the corticosterone (CORT) response to stress with and without dexamethasone (DEX) and anxiety-like behaviors. Following the DEX suppression test and behavioral assays, half of the cohort engaged in 6 weeks of EtOH drinking in a homecage, two-bottle choice intermittent access model. A subset of the cohort was not exposed to EtOH, but was used for electrophysiological measurement of glutamatergic synaptic plasticity in the basolateral amygdala (BLA). Correlational analyses examined relationships between measures of CORT, anxiety-like behaviors, and EtOH intake/preference. With DEX pre-treatment, SI rats failed to suppress CORT in response to an acute stress; GH rats showed a significant suppression. In SI rats, there was a significant negative correlation between baseline CORT and elevated plus maze open arm time, as well as significant positive correlations between baseline CORT and both EtOH intake and preference. No significant relationships between baseline CORT and behavioral measures were observed in GH rats. Glutamatergic plasticity in the BLA was similar in magnitude between GH and SI rats, and was not altered by exogenous application of CORT. These data suggest that HPA axis function is affected by SI, and this is related to antecedent anxiety-like behavior and may predispose for future EtOH self-administration. Relationships between HPA axis function, anxiety, and EtOH measures in SI rats further strengthens the utility of this paradigm in modeling vulnerability for affective disorders and alcoholism. |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Austria | 1 | <1% |
| Canada | 1 | <1% |
| Argentina | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 120 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 19% |
| Student > Bachelor | 20 | 16% |
| Researcher | 18 | 14% |
| Student > Master | 14 | 11% |
| Student > Doctoral Student | 9 | 7% |
| Other | 23 | 18% |
| Unknown | 17 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 26% |
| Neuroscience | 28 | 22% |
| Psychology | 20 | 16% |
| Biochemistry, Genetics and Molecular Biology | 8 | 6% |
| Medicine and Dentistry | 7 | 6% |
| Other | 11 | 9% |
| Unknown | 18 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2014.
All research outputs
#15,295,786
of 22,747,498 outputs
Outputs from Frontiers in Integrative Neuroscience
#595
of 853 outputs
Outputs of similar age
#189,983
of 305,224 outputs
Outputs of similar age from Frontiers in Integrative Neuroscience
#13
of 20 outputs
Altmetric has tracked 22,747,498 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 853 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,224 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.