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Role of GSK3 Signaling in Neuronal Morphogenesis

Overview of attention for article published in Frontiers in Molecular Neuroscience, January 2011
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Title
Role of GSK3 Signaling in Neuronal Morphogenesis
Published in
Frontiers in Molecular Neuroscience, January 2011
DOI 10.3389/fnmol.2011.00048
Pubmed ID
Authors

Yun Tai Kim, Eun-Mi Hur, William D. Snider, Feng-Quan Zhou

Abstract

Glycogen synthase kinase 3 (GSK3) is emerging as a key regulator of several aspects of neuronal morphogenesis including neuronal polarization, axon growth, and axon branching. Multiple signaling pathways have been identified that control neuronal polarization, including PI3K, Rho-GTPases, Par3/6, TSC-mTOR, and PKA-LKB1. However, how these pathways are coordinated is not clear. As GSK3 signaling exhibits crosstalk with each of these pathways it has the potential to integrate these polarity signals in the control neuronal polarization. After neurons establish polarity, GSK3 acts as an important signaling mediator in the regulation of axon extension and axon branching by transducing upstream signaling to reorganization of the axonal cytoskeleton, especially microtubules. Here we review the roles of GSK3 signaling in neuronal morphogenesis and discuss the underlying molecular mechanisms.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 2 1%
Japan 2 1%
Canada 1 <1%
France 1 <1%
United States 1 <1%
Unknown 141 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 42 28%
Researcher 28 19%
Student > Bachelor 15 10%
Student > Master 15 10%
Professor > Associate Professor 9 6%
Other 19 13%
Unknown 20 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 62 42%
Neuroscience 27 18%
Biochemistry, Genetics and Molecular Biology 26 18%
Medicine and Dentistry 5 3%
Engineering 2 1%
Other 6 4%
Unknown 20 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2011.
All research outputs
#20,165,369
of 22,675,759 outputs
Outputs from Frontiers in Molecular Neuroscience
#2,436
of 2,826 outputs
Outputs of similar age
#169,848
of 180,328 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#25
of 27 outputs
Altmetric has tracked 22,675,759 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,826 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.