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Ca2+-permeable AMPA receptors in homeostatic synaptic plasticity

Overview of attention for article published in Frontiers in Molecular Neuroscience, January 2012
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Title
Ca2+-permeable AMPA receptors in homeostatic synaptic plasticity
Published in
Frontiers in Molecular Neuroscience, January 2012
DOI 10.3389/fnmol.2012.00017
Pubmed ID
Authors

Hey-Kyoung Lee

Abstract

Neurons possess diverse mechanisms of homeostatic adaptation to overall changes in neural and synaptic activity, which are critical for proper brain functions. Homeostatic regulation of excitatory synapses has been studied in the context of synaptic scaling, which allows neurons to adjust their excitatory synaptic gain to maintain their activity within a dynamic range. Recent evidence suggests that one of the main mechanisms underlying synaptic scaling is by altering the function of postsynaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), including synaptic expression of Ca(2+)-permeable (CP-) AMPARs. CP-AMPARs endow synapses with unique properties, which may benefit adaptation of neurons to periods of inactivity as would occur when a major input is lost. This review will summarize how synaptic expression of CP-AMPARs is regulated during homeostatic synaptic plasticity in the context of synaptic scaling, and will address the potential functional consequences of altering synaptic CP-AMPAR content.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 4%
Israel 1 <1%
Germany 1 <1%
Canada 1 <1%
United Kingdom 1 <1%
Unknown 112 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 34%
Researcher 19 16%
Student > Master 15 12%
Student > Bachelor 10 8%
Professor 8 7%
Other 16 13%
Unknown 12 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 47 39%
Neuroscience 39 32%
Biochemistry, Genetics and Molecular Biology 6 5%
Medicine and Dentistry 6 5%
Psychology 3 2%
Other 6 5%
Unknown 14 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2012.
All research outputs
#15,243,549
of 22,665,794 outputs
Outputs from Frontiers in Molecular Neuroscience
#1,813
of 2,822 outputs
Outputs of similar age
#163,131
of 244,050 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#24
of 48 outputs
Altmetric has tracked 22,665,794 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,822 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,050 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.