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Mendeley readers
Attention Score in Context
| Title |
Physiology of quantal norepinephrine release from somatodendritic sites of neurons in locus coeruleus
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, January 2012
|
| DOI | 10.3389/fnmol.2012.00029 |
| Pubmed ID | |
| Authors |
Hong-Ping Huang, Fei-Peng Zhu, Xiao-Wei Chen, Zhi-Qing David Xu, Claire Xi Zhang, Zhuan Zhou |
| Abstract |
Norepinephrine (NE) released from the nerve terminal of locus coeruleus (LC) neurons contributes to about 70% of the total extracellular NE in primates brain. In addition, LC neurons also release NE from somatodendritic sites. Quantal NE release from soma of LC neurons has the characteristics of long latency, nerve activity-dependency, and autoinhibition by α(2)-adrenergic autoreceptor. The distinct kinetics of stimulus-secretion coupling in somata is regulated by action potential patterns. The physiological significance of soma and dendritic release is to produce negative-feedback and to down-regulate neuronal hyperactivity, which consequently inhibit NE release from axon terminal of LC projecting to many brain areas. Recent discoveries about the LC somatodendritic release may provide new insights into the pathogenesis of clinic disease involving LC-NE system dysfunction, and may help developing remedy targeted to the LC area. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 2% |
| Italy | 1 | 2% |
| Unknown | 47 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 27% |
| Researcher | 10 | 20% |
| Student > Master | 8 | 16% |
| Student > Bachelor | 6 | 12% |
| Student > Postgraduate | 2 | 4% |
| Other | 4 | 8% |
| Unknown | 6 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 18 | 37% |
| Agricultural and Biological Sciences | 9 | 18% |
| Medicine and Dentistry | 4 | 8% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Chemistry | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 9 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2012.
All research outputs
#15,246,403
of 22,669,724 outputs
Outputs from Frontiers in Molecular Neuroscience
#1,814
of 2,823 outputs
Outputs of similar age
#163,162
of 244,072 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#24
of 48 outputs
Altmetric has tracked 22,669,724 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,823 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,072 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.