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Drug-evoked plasticity: do addictive drugs reopen a critical period of postnatal synaptic development?

Overview of attention for article published in Frontiers in Molecular Neuroscience, January 2012
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Title
Drug-evoked plasticity: do addictive drugs reopen a critical period of postnatal synaptic development?
Published in
Frontiers in Molecular Neuroscience, January 2012
DOI 10.3389/fnmol.2012.00075
Pubmed ID
Authors

Bellone, Camilla, Luscher, Christian

Abstract

As in other parts of the central nervous system (CNS) of the mouse, glutamatergic synapses onto dopamine (DA) neurons in the ventral tegmental area (VTA) mature postnatally. At birth many AMPA receptors (AMPARs) lack GluA2R subunit and most NMDARs contain the GluN2B subunit. Within 2 weeks these receptors are replaced with GluA2- and GluN2A- containing AMPARs and NMDARs, respectively. Recent data suggest that a single injection of cocaine (or another drug of addiction) triggers glutamate receptor redistribution with the reappearance of the subunits typically present in immature synapses, as if addictive drugs reopen the developmental critical period. Here we review the experimental evidence for this hypothesis and discuss the implications for circuit function.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 5%
Switzerland 2 3%
United Kingdom 1 1%
Belgium 1 1%
Canada 1 1%
Unknown 67 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 22%
Researcher 14 18%
Student > Master 10 13%
Professor 9 12%
Student > Bachelor 5 7%
Other 13 17%
Unknown 8 11%
Readers by discipline Count As %
Neuroscience 25 33%
Agricultural and Biological Sciences 22 29%
Biochemistry, Genetics and Molecular Biology 5 7%
Psychology 5 7%
Medicine and Dentistry 4 5%
Other 6 8%
Unknown 9 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2014.
All research outputs
#18,375,064
of 22,758,963 outputs
Outputs from Frontiers in Molecular Neuroscience
#2,256
of 2,851 outputs
Outputs of similar age
#196,161
of 244,293 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#35
of 48 outputs
Altmetric has tracked 22,758,963 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,851 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
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