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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Telomere length is highly inherited and associated with hyperactivity-impulsivity in children with attention deficit/hyperactivity disorder
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, July 2015
|
| DOI | 10.3389/fnmol.2015.00028 |
| Pubmed ID | |
| Authors |
Danielle de Souza Costa, Daniela Valadão Freitas Rosa, Alexandre Guimarães Almeida Barros, Marco Aurélio Romano-Silva, Leandro Fernandes Malloy-Diniz, Paulo Mattos, Débora Marques de Miranda |
| Abstract |
Telomere length (TL) is highly heritable, and a shorter telomere at birth may increase the risk of age-related problems. Additionally, a shorter TL may represent a biomarker of chronic stress and has been associated with psychiatric disorders. However, no study has explored whether there is an association between TL and the symptoms of one of the most common neurodevelopmental disorders in childhood: Attention Deficit/Hyperactive Disorder (ADHD). We evaluated 61 (range, 6-16 years) ADHD children and their parents between 2012 and 2014. TL was measured with a quantitative polymerase chain reaction method with telomere signal normalized to the signal from a single copy gene (36B4) to generate a T/S ratio. Family data was processed through a generalized estimated equations (GEE) model to determine the effect of parental TL on children TL. Inattentive and hyperactive-impulsive symptoms were also evaluated in relation to TL. For the first time, we found general heritability to be the major mechanism explaining interindividual TL variation in ADHD (father-child: 95% CI = 0.35/0.91, p < 0.001; mother-child: 95% CI = 0.38/0.74, p < 0.001). The hyperactive-impulsive dimension of ADHD was related with children's TL (r = -339, p = 0.008) and maternal TL (r = -264, p = 0.047), but not with paternal TL (p > 0.05). The ADHD inattentive dimension was not significant associated with TL in this study (p > 0.05). TL was shown to be a potential biomarker of the ADHD symptoms burden in families affected by this neurodevelopmental disorder. However, it is crucial that future studies investigating the rate of telomere attrition in relation to psychiatric problems to consider the strong determination of TL at birth by inheritance. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 17% |
| United States | 2 | 17% |
| United Kingdom | 1 | 8% |
| Switzerland | 1 | 8% |
| Brazil | 1 | 8% |
| Unknown | 5 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 67% |
| Practitioners (doctors, other healthcare professionals) | 2 | 17% |
| Scientists | 2 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Mexico | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 85 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 19% |
| Researcher | 17 | 19% |
| Student > Master | 14 | 16% |
| Student > Bachelor | 7 | 8% |
| Other | 7 | 8% |
| Other | 12 | 14% |
| Unknown | 14 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 16% |
| Agricultural and Biological Sciences | 14 | 16% |
| Psychology | 12 | 14% |
| Biochemistry, Genetics and Molecular Biology | 10 | 11% |
| Neuroscience | 4 | 5% |
| Other | 14 | 16% |
| Unknown | 20 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 33. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2015.
All research outputs
#1,230,988
of 25,654,806 outputs
Outputs from Frontiers in Molecular Neuroscience
#84
of 3,364 outputs
Outputs of similar age
#14,828
of 277,831 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#1
of 28 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,364 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,831 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.