Title |
NF-κB transcription factor role in consolidation and reconsolidation of persistent memories
|
---|---|
Published in |
Frontiers in Molecular Neuroscience, September 2015
|
DOI | 10.3389/fnmol.2015.00050 |
Pubmed ID | |
Authors |
Verónica de la Fuente, Noel Federman, Gisela Zalcman, Angeles Salles, Ramiro Freudenthal, Arturo Romano |
Abstract |
Transcriptional regulation is an important molecular process required for long-term neural plasticity and long-term memory (LTM) formation. Thus, one main interest in molecular neuroscience in the last decades has been the identification of transcription factors that are involved in memory processes. Among them, the nuclear factor κB (NF-κB) family of transcription factors has gained interest due to a significant body of evidence that supports a key role of these proteins in synaptic plasticity and memory. In recent years, the interest was particularly reinforced because NF-κB was characterized as an important regulator of synaptogenesis. This function may be explained by its participation in synapse to nucleus communication, as well as a possible local role at the synapse. This review provides an overview of experimental work obtained in the last years, showing the essential role of this transcription factor in memory processes in different learning tasks in mammals. We focus the review on the consolidation and reconsolidation memory phases as well as on the regulation of immediate-early and late genes by epigenetic mechanisms that determine enduring forms of memories. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 17% |
France | 1 | 17% |
Switzerland | 1 | 17% |
United States | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Italy | 1 | 2% |
Unknown | 40 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 8 | 19% |
Researcher | 7 | 17% |
Student > Master | 7 | 17% |
Student > Ph. D. Student | 3 | 7% |
Professor | 2 | 5% |
Other | 8 | 19% |
Unknown | 7 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 21% |
Neuroscience | 7 | 17% |
Biochemistry, Genetics and Molecular Biology | 6 | 14% |
Psychology | 5 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 4 | 10% |
Unknown | 10 | 24% |