Title |
Evaluation of Gene Therapy as an Intervention Strategy to Treat Brain Injury from Stroke
|
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Published in |
Frontiers in Molecular Neuroscience, May 2016
|
DOI | 10.3389/fnmol.2016.00034 |
Pubmed ID | |
Authors |
Amanda J. Craig, Gary D. Housley |
Abstract |
Stroke is a leading cause of death and disability, with a lack of treatments available to prevent cell death, regenerate damaged cells and pathways, or promote neurogenesis. The extended period of hours to weeks over which tissue damage continues to occur makes this disorder a candidate for gene therapy. This review highlights the development of gene therapy in the area of stroke, with the evolution of viral administration, in experimental stroke models, from pre-injury to clinically relevant timeframes of hours to days post-stroke. The putative therapeutic proteins being examined include anti-apoptotic, pro-survival, anti-inflammatory, and guidance proteins, targeting multiple pathways within the complex pathology, with promising results. The balance of findings from animal models suggests that gene therapy provides a viable translational platform for treatment of ischemic brain injury arising from stroke. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 20% |
Iraq | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 53 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 19% |
Student > Bachelor | 9 | 17% |
Researcher | 7 | 13% |
Student > Doctoral Student | 6 | 11% |
Other | 4 | 8% |
Other | 8 | 15% |
Unknown | 9 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 17% |
Neuroscience | 8 | 15% |
Medicine and Dentistry | 8 | 15% |
Agricultural and Biological Sciences | 6 | 11% |
Engineering | 4 | 8% |
Other | 7 | 13% |
Unknown | 11 | 21% |