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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Versatile Structures of α-Synuclein
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, June 2016
|
| DOI | 10.3389/fnmol.2016.00048 |
| Pubmed ID | |
| Authors |
Chuchu Wang, Chunyu Zhao, Dan Li, Zhiqi Tian, Ying Lai, Jiajie Diao, Cong Liu |
| Abstract |
α-Synuclein (α-syn) is an intrinsically disordered protein abundantly distributed in presynaptic terminals. Aggregation of α-syn into Lewy bodies (LB) is a molecular hallmark of Parkinson's disease (PD). α-Syn features an extreme conformational diversity, which adapts to different conditions and fulfills versatile functions. However, the molecular mechanism of α-syn transformation and the relation between different structural species and their functional and pathogenic roles in neuronal activities and PD remain unknown. In this mini-review, we summarize the recent discoveries of α-syn structures in the membrane-bound state, in cytosol, and in the amyloid state under physiological and pathological conditions. From the current knowledge on different structural species of α-syn, we intend to find a clue about its function and toxicity in normal neurons and under disease conditions, which could shed light on the PD pathogenesis. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 192 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Israel | 1 | <1% |
| Unknown | 191 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 19% |
| Researcher | 27 | 14% |
| Student > Bachelor | 25 | 13% |
| Student > Master | 24 | 13% |
| Professor | 8 | 4% |
| Other | 24 | 13% |
| Unknown | 47 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 60 | 31% |
| Agricultural and Biological Sciences | 24 | 13% |
| Neuroscience | 17 | 9% |
| Chemistry | 13 | 7% |
| Medicine and Dentistry | 7 | 4% |
| Other | 20 | 10% |
| Unknown | 51 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2016.
All research outputs
#14,275,291
of 23,321,213 outputs
Outputs from Frontiers in Molecular Neuroscience
#1,468
of 2,972 outputs
Outputs of similar age
#198,721
of 355,394 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#14
of 31 outputs
Altmetric has tracked 23,321,213 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,972 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 355,394 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.