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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Ammonia as a Potential Neurotoxic Factor in Alzheimer's Disease
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, August 2016
|
| DOI | 10.3389/fnmol.2016.00057 |
| Pubmed ID | |
| Authors |
Aida Adlimoghaddam, Mohammad G. Sabbir, Benedict C. Albensi |
| Abstract |
Ammonia is known to be a potent neurotoxin that causes severe negative effects on the central nervous system. Excessive ammonia levels have been detected in the brain of patients with neurological disorders such as Alzheimer disease (AD). Therefore, ammonia could be a factor contributing to the progression of AD. In this review, we provide an introduction to the toxicity of ammonia and putative ammonia transport proteins. We also hypothesize how ammonia may be linked to AD. Additionally, we discuss the evidence that support the hypothesis that ammonia is a key factor contributing to AD progression. Lastly, we summarize the old and new experimental evidence that focuses on energy metabolism, mitochondrial function, inflammatory responses, excitatory glutamatergic, and GABAergic neurotransmission, and memory in support of our ammonia-related hypotheses of AD. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 43% |
| Canada | 3 | 21% |
| Unknown | 5 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 71% |
| Practitioners (doctors, other healthcare professionals) | 2 | 14% |
| Science communicators (journalists, bloggers, editors) | 1 | 7% |
| Scientists | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 94 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 20% |
| Student > Master | 17 | 18% |
| Student > Doctoral Student | 9 | 10% |
| Student > Bachelor | 6 | 6% |
| Other | 5 | 5% |
| Other | 16 | 17% |
| Unknown | 22 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 16% |
| Neuroscience | 13 | 14% |
| Biochemistry, Genetics and Molecular Biology | 11 | 12% |
| Medicine and Dentistry | 9 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Other | 19 | 20% |
| Unknown | 22 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2023.
All research outputs
#2,060,450
of 25,789,020 outputs
Outputs from Frontiers in Molecular Neuroscience
#172
of 3,379 outputs
Outputs of similar age
#36,961
of 380,213 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#3
of 40 outputs
Altmetric has tracked 25,789,020 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,379 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 380,213 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.