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Attention Score in Context
| Title |
Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, December 2016
|
| DOI | 10.3389/fnmol.2016.00137 |
| Pubmed ID | |
| Authors |
Csilla Ari, Zsolt Kovács, Gabor Juhasz, Cem Murdun, Craig R. Goldhagen, Andrew P. Koutnik, Angela M. Poff, Shannon L. Kesl, Dominic P. D’Agostino |
| Abstract |
Nutritional ketosis has been proven effective for seizure disorders and other neurological disorders. The focus of this study was to determine the effects of ketone supplementation on anxiety-related behavior in Sprague-Dawley (SPD) and Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. We tested exogenous ketone supplements added to food and fed chronically for 83 days in SPD rats and administered sub-chronically for 7 days in both rat models by daily intragastric gavage bolus followed by assessment of anxiety measures on elevated plus maze (EPM). The groups included standard diet (SD) or SD + ketone supplementation. Low-dose ketone ester (LKE; 1,3-butanediol-acetoacetate diester, ~10 g/kg/day, LKE), high dose ketone ester (HKE; ~25 g/kg/day, HKE), beta-hydroxybutyrate-mineral salt (βHB-S; ~25 g/kg/day, KS) and βHB-S + medium chain triglyceride (MCT; ~25 g/kg/day, KSMCT) were used as ketone supplementation for chronic administration. To extend our results, exogenous ketone supplements were also tested sub-chronically on SPD rats (KE, KS and KSMCT; 5 g/kg/day) and on WAG/Rij rats (KE, KS and KSMCT; 2.5 g/kg/day). At the end of treatments behavioral data collection was conducted manually by a blinded observer and with a video-tracking system, after which blood βHB and glucose levels were measured. Ketone supplementation reduced anxiety on EPM as measured by less entries to closed arms (sub-chronic KE and KS: SPD rats and KSMCT: WAG/Rij rats), more time spent in open arms (sub-chronic KE: SPD and KSMCT: WAG/Rij rats; chronic KSMCT: SPD rats), more distance traveled in open arms (chronic KS and KSMCT: SPD rats) and by delayed latency to entrance to closed arms (chronic KSMCT: SPD rats), when compared to control. Our data indicates that chronic and sub-chronic ketone supplementation not only elevated blood βHB levels in both animal models, but reduced anxiety-related behavior. We conclude that ketone supplementation may represent a promising anxiolytic strategy through a novel means of inducing nutritional ketosis. |
X Demographics
The data shown below were collected from the profiles of 50 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 20 | 40% |
| United Kingdom | 4 | 8% |
| Chile | 2 | 4% |
| Canada | 2 | 4% |
| Switzerland | 1 | 2% |
| Australia | 1 | 2% |
| Italy | 1 | 2% |
| Ireland | 1 | 2% |
| Côte d'Ivoire | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 17 | 34% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 38 | 76% |
| Practitioners (doctors, other healthcare professionals) | 7 | 14% |
| Scientists | 5 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 124 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 22 | 18% |
| Student > Ph. D. Student | 21 | 17% |
| Researcher | 17 | 14% |
| Student > Bachelor | 15 | 12% |
| Professor | 6 | 5% |
| Other | 17 | 14% |
| Unknown | 27 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 21 | 17% |
| Biochemistry, Genetics and Molecular Biology | 16 | 13% |
| Agricultural and Biological Sciences | 13 | 10% |
| Medicine and Dentistry | 10 | 8% |
| Psychology | 9 | 7% |
| Other | 21 | 17% |
| Unknown | 35 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 60. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2023.
All research outputs
#711,584
of 25,483,400 outputs
Outputs from Frontiers in Molecular Neuroscience
#40
of 3,346 outputs
Outputs of similar age
#14,507
of 420,909 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#2
of 70 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,346 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 420,909 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.