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Mendeley readers
Attention Score in Context
| Title |
Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, December 2016
|
| DOI | 10.3389/fnmol.2016.00155 |
| Pubmed ID | |
| Authors |
Sonoko Hasegawa, Makiko Kumagai, Mitsue Hagihara, Hiroshi Nishimaru, Keizo Hirano, Ryosuke Kaneko, Atsushi Okayama, Teruyoshi Hirayama, Makoto Sanbo, Masumi Hirabayashi, Masahiko Watanabe, Takahiro Hirabayashi, Takeshi Yagi |
| Abstract |
The clustered protocadherin (Pcdh) genes are divided into the Pcdhα, Pcdhβ, and Pcdhγ clusters. Gene-disruption analyses in mice have revealed the in vivo functions of the Pcdhα and Pcdhγ clusters. However, all Pcdh protein isoforms form combinatorial cis-hetero dimers and enter trans-homophilic interactions. Here we addressed distinct and cooperative functions in the Pcdh clusters by generating six cluster-deletion mutants (Δα, Δβ, Δγ, Δαβ, Δβγ, and Δαβγ) and comparing their phenotypes: Δα, Δβ, and Δαβ mutants were viable and fertile; Δγ mutants lived less than 12 h; and Δβγ and Δαβγ mutants died shortly after birth. The Pcdhα, Pcdhβ, and Pcdhγ clusters were individually and cooperatively important in olfactory-axon targeting and spinal-cord neuron survival. Neurodegeneration was most severe in Δαβγ mutants, indicating that Pcdhα and Pcdhβ function cooperatively for neuronal survival. The Pcdhα, Pcdhβ, and Pcdhγ clusters share roles in olfactory-axon targeting and neuronal survival, although to different degrees. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 48 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 19% |
| Researcher | 8 | 17% |
| Student > Master | 7 | 15% |
| Student > Bachelor | 4 | 8% |
| Professor > Associate Professor | 3 | 6% |
| Other | 3 | 6% |
| Unknown | 14 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 21% |
| Neuroscience | 10 | 21% |
| Biochemistry, Genetics and Molecular Biology | 5 | 10% |
| Medicine and Dentistry | 3 | 6% |
| Psychology | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 16 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 December 2016.
All research outputs
#20,376,559
of 22,925,760 outputs
Outputs from Frontiers in Molecular Neuroscience
#2,483
of 2,895 outputs
Outputs of similar age
#354,635
of 420,129 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#68
of 81 outputs
Altmetric has tracked 22,925,760 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,895 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.