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X Demographics
Mendeley readers
Attention Score in Context
| Title |
APP as a Protective Factor in Acute Neuronal Insults
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, February 2017
|
| DOI | 10.3389/fnmol.2017.00022 |
| Pubmed ID | |
| Authors |
Dimitri Hefter, Andreas Draguhn |
| Abstract |
Despite its key role in the molecular pathology of Alzheimer's disease (AD), the physiological function of amyloid precursor protein (APP) is unknown. Increasing evidence, however, points towards a neuroprotective role of this membrane protein in situations of metabolic stress. A key observation is the up-regulation of APP following acute (stroke, cardiac arrest) or chronic (cerebrovascular disease) hypoxic-ischemic conditions. While this mechanism may increase the risk or severity of AD, APP by itself or its soluble extracellular fragment APPsα can promote neuronal survival. Indeed, different animal models of acute hypoxia-ischemia, traumatic brain injury (TBI) and excitotoxicity have revealed protective effects of APP or APPsα. The underlying mechanisms involve APP-mediated regulation of calcium homeostasis via NMDA receptors (NMDAR), voltage-gated calcium channels (VGCC) or internal calcium stores. In addition, APP affects the expression of survival- or apoptosis-related genes as well as neurotrophic factors. In this review, we summarize the current understanding of the neuroprotective role of APP and APPsα and possible implications for future research and new therapeutic strategies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | <1% |
| Unknown | 100 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 19% |
| Researcher | 19 | 19% |
| Student > Bachelor | 17 | 17% |
| Student > Master | 14 | 14% |
| Student > Postgraduate | 7 | 7% |
| Other | 10 | 10% |
| Unknown | 15 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 30 | 30% |
| Biochemistry, Genetics and Molecular Biology | 14 | 14% |
| Agricultural and Biological Sciences | 13 | 13% |
| Medicine and Dentistry | 10 | 10% |
| Computer Science | 3 | 3% |
| Other | 13 | 13% |
| Unknown | 18 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 February 2017.
All research outputs
#3,219,938
of 22,950,943 outputs
Outputs from Frontiers in Molecular Neuroscience
#506
of 2,898 outputs
Outputs of similar age
#69,696
of 420,304 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#22
of 99 outputs
Altmetric has tracked 22,950,943 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,898 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 420,304 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.