Title |
The Role of Astrocytes in Neuroprotection after Brain Stroke: Potential in Cell Therapy
|
---|---|
Published in |
Frontiers in Molecular Neuroscience, April 2017
|
DOI | 10.3389/fnmol.2017.00088 |
Pubmed ID | |
Authors |
Andrea Becerra-Calixto, Gloria P. Cardona-Gómez |
Abstract |
Astrocytes are commonly involved in negative responses through their hyperreactivity and glial scar formation in excitotoxic and/or mechanical injuries. But, astrocytes are also specialized glial cells of the nervous system that perform multiple homeostatic functions for the survival and maintenance of the neurovascular unit. Astrocytes have neuroprotective, angiogenic, immunomodulatory, neurogenic, and antioxidant properties and modulate synaptic function. This makes them excellent candidates as a source of neuroprotection and neurorestoration in tissues affected by ischemia/reperfusion, when some of their deregulated genes can be controlled. Therefore, this review analyzes pro-survival responses of astrocytes that would allow their use in cell therapy strategies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 7% |
Venezuela, Bolivarian Republic of | 1 | 4% |
Uruguay | 1 | 4% |
Peru | 1 | 4% |
Switzerland | 1 | 4% |
France | 1 | 4% |
Canada | 1 | 4% |
Brazil | 1 | 4% |
Turkey | 1 | 4% |
Other | 3 | 11% |
Unknown | 14 | 52% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 20 | 74% |
Scientists | 7 | 26% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | <1% |
Unknown | 337 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 64 | 19% |
Student > Bachelor | 59 | 17% |
Student > Master | 45 | 13% |
Researcher | 44 | 13% |
Student > Doctoral Student | 18 | 5% |
Other | 38 | 11% |
Unknown | 70 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 99 | 29% |
Agricultural and Biological Sciences | 46 | 14% |
Biochemistry, Genetics and Molecular Biology | 44 | 13% |
Medicine and Dentistry | 24 | 7% |
Engineering | 11 | 3% |
Other | 32 | 9% |
Unknown | 82 | 24% |