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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, May 2017
|
| DOI | 10.3389/fnmol.2017.00123 |
| Pubmed ID | |
| Authors |
Christopher P Webster, Emma F Smith, Pamela J Shaw, Kurt J De Vos |
| Abstract |
Protein homeostasis (proteostasis), the correct balance between production and degradation of proteins, is essential for the health and survival of cells. Proteostasis requires an intricate network of protein quality control pathways (the proteostasis network) that work to prevent protein aggregation and maintain proteome health throughout the lifespan of the cell. Collapse of proteostasis has been implicated in the etiology of a number of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), the most common adult onset motor neuron disorder. Here, we review the evidence linking dysfunctional proteostasis to the etiology of ALS and discuss how ALS-associated insults affect the proteostasis network. Finally, we discuss the potential therapeutic benefit of proteostasis network modulation in ALS. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 36% |
| United States | 3 | 21% |
| Ireland | 1 | 7% |
| Canada | 1 | 7% |
| Unknown | 4 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 57% |
| Scientists | 5 | 36% |
| Practitioners (doctors, other healthcare professionals) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 178 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | <1% |
| Unknown | 177 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 23% |
| Student > Bachelor | 26 | 15% |
| Student > Master | 24 | 13% |
| Researcher | 13 | 7% |
| Student > Doctoral Student | 9 | 5% |
| Other | 20 | 11% |
| Unknown | 45 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 44 | 25% |
| Neuroscience | 37 | 21% |
| Agricultural and Biological Sciences | 20 | 11% |
| Medicine and Dentistry | 11 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 14 | 8% |
| Unknown | 47 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2018.
All research outputs
#2,125,968
of 25,728,350 outputs
Outputs from Frontiers in Molecular Neuroscience
#179
of 3,374 outputs
Outputs of similar age
#38,757
of 325,816 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#5
of 115 outputs
Altmetric has tracked 25,728,350 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,374 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 325,816 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 115 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.