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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, May 2017
|
| DOI | 10.3389/fnmol.2017.00170 |
| Pubmed ID | |
| Authors |
Mauricio Budini, Emanuele Buratti, Eugenia Morselli, Alfredo Criollo |
| Abstract |
Autophagy is a catabolic mechanism where intracellular material is degraded by vesicular structures called autophagolysosomes. Autophagy is necessary to maintain the normal function of the central nervous system (CNS), avoiding the accumulation of misfolded and aggregated proteins. Consistently, impaired autophagy has been associated with the pathogenesis of various neurodegenerative diseases. The proteins TAR DNA-binding protein-43 (TDP-43), which regulates RNA processing at different levels, and chromosome 9 open reading frame 72 (C9orf72), probably involved in membrane trafficking, are crucial in the development of neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). Additionally, recent studies have identified a role for these proteins in the control of autophagy. In this manuscript, we review what is known regarding the autophagic mechanism and discuss the involvement of TDP-43 and C9orf72 in autophagy and their impact on neurodegenerative diseases. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 17% |
| France | 1 | 17% |
| Chile | 1 | 17% |
| Switzerland | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Scientists | 2 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 179 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 179 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 18% |
| Student > Bachelor | 27 | 15% |
| Researcher | 22 | 12% |
| Student > Master | 19 | 11% |
| Student > Doctoral Student | 14 | 8% |
| Other | 28 | 16% |
| Unknown | 36 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 52 | 29% |
| Neuroscience | 33 | 18% |
| Agricultural and Biological Sciences | 26 | 15% |
| Medicine and Dentistry | 9 | 5% |
| Chemistry | 6 | 3% |
| Other | 17 | 9% |
| Unknown | 36 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2017.
All research outputs
#14,601,153
of 25,375,376 outputs
Outputs from Frontiers in Molecular Neuroscience
#1,390
of 3,329 outputs
Outputs of similar age
#159,243
of 322,592 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#52
of 117 outputs
Altmetric has tracked 25,375,376 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,329 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,592 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 117 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.