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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Low-Fat Diet With Caloric Restriction Reduces White Matter Microglia Activation During Aging
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, March 2018
|
| DOI | 10.3389/fnmol.2018.00065 |
| Pubmed ID | |
| Authors |
Zhuoran Yin, Divya D. Raj, Wandert Schaafsma, Roel A. van der Heijden, Susanne M. Kooistra, Aaffien C. Reijne, Xiaoming Zhang, Jill Moser, Nieske Brouwer, Peter Heeringa, Chun-Xia Yi, Gertjan van Dijk, Jon D. Laman, Erik W. G. M. Boddeke, Bart J. L. Eggen |
| Abstract |
Rodent models of both aging and obesity are characterized by inflammation in specific brain regions, notably the corpus callosum, fornix, and hypothalamus. Microglia, the resident macrophages of the central nervous system, are important for brain development, neural support, and homeostasis. However, the effects of diet and lifestyle on microglia during aging are only partly understood. Here, we report alterations in microglia phenotype and functions in different brain regions of mice on a high-fat diet (HFD) or low-fat diet (LFD) during aging and in response to voluntary running wheel exercise. We compared the expression levels of genes involved in immune response, phagocytosis, and metabolism in the hypothalamus of 6-month-old HFD and LFD mice. We also compared the immune response of microglia from HFD or LFD mice to peripheral inflammation induced by intraperitoneal injection of lipopolysaccharide (LPS). Finally, we investigated the effect of diet, physical exercise, and caloric restriction (40% reduction compared toad libitumintake) on microglia in 24-month-old HFD and LFD mice. Changes in diet caused morphological changes in microglia, but did not change the microglia response to LPS-induced systemic inflammation. Expression of phagocytic markers (i.e., Mac-2/Lgals3, Dectin-1/Clec7a, and CD16/CD32) in the white matter microglia of 24-month-old brain was markedly decreased in calorically restricted LFD mice. In conclusion, LFD resulted in reduced activation of microglia, which might be an underlying mechanism for the protective role of caloric restriction during aging-associated decline. |
X Demographics
The data shown below were collected from the profiles of 39 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 18% |
| Spain | 4 | 10% |
| Netherlands | 4 | 10% |
| United Kingdom | 2 | 5% |
| Canada | 2 | 5% |
| Switzerland | 1 | 3% |
| Finland | 1 | 3% |
| Poland | 1 | 3% |
| Italy | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 13 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 24 | 62% |
| Scientists | 9 | 23% |
| Practitioners (doctors, other healthcare professionals) | 6 | 15% |
Mendeley readers
The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 128 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 24 | 19% |
| Student > Ph. D. Student | 22 | 17% |
| Researcher | 17 | 13% |
| Student > Master | 17 | 13% |
| Professor | 8 | 6% |
| Other | 24 | 19% |
| Unknown | 16 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 35 | 27% |
| Biochemistry, Genetics and Molecular Biology | 14 | 11% |
| Agricultural and Biological Sciences | 14 | 11% |
| Medicine and Dentistry | 11 | 9% |
| Nursing and Health Professions | 10 | 8% |
| Other | 20 | 16% |
| Unknown | 24 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 165. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2023.
All research outputs
#248,876
of 25,582,611 outputs
Outputs from Frontiers in Molecular Neuroscience
#15
of 3,360 outputs
Outputs of similar age
#5,772
of 350,998 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#2
of 125 outputs
Altmetric has tracked 25,582,611 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,360 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 350,998 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.