Title |
The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders
|
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Published in |
Frontiers in Molecular Neuroscience, May 2018
|
DOI | 10.3389/fnmol.2018.00169 |
Pubmed ID | |
Authors |
Gonca Bayraktar, Michael R. Kreutz |
Abstract |
Over the last decade, an increasing number of reports underscored the importance of epigenetic regulations in brain plasticity. Epigenetic elements such as readers, writers and erasers recognize, establish, and remove the epigenetic tags in nucleosomes, respectively. One such regulation concerns DNA-methylation and demethylation, which are highly dynamic and activity-dependent processes even in the adult neurons. It is nowadays widely believed that external stimuli control the methylation marks on the DNA and that such processes serve transcriptional regulation in neurons. In this mini-review, we cover the current knowledge on the regulatory mechanisms controlling in particular DNA demethylation as well as the possible functional consequences in health and disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 10% |
Switzerland | 1 | 10% |
Unknown | 8 | 80% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 80% |
Scientists | 2 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 72 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 14% |
Researcher | 7 | 10% |
Student > Master | 7 | 10% |
Student > Bachelor | 6 | 8% |
Student > Doctoral Student | 3 | 4% |
Other | 13 | 18% |
Unknown | 26 | 36% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 12 | 17% |
Neuroscience | 12 | 17% |
Agricultural and Biological Sciences | 7 | 10% |
Medicine and Dentistry | 6 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
Other | 7 | 10% |
Unknown | 27 | 38% |