Title |
Opposite Roles of Wnt7a and Sfrp1 in Modulating Proper Development of Neural Progenitors in the Mouse Cerebral Cortex
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Published in |
Frontiers in Molecular Neuroscience, July 2018
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DOI | 10.3389/fnmol.2018.00247 |
Pubmed ID | |
Authors |
Nan Miao, Shan Bian, Trevor Lee, Taufif Mubarak, Shiying Huang, Zhihong Wen, Ghulam Hussain, Tao Sun |
Abstract |
The Wingless (Wnt)-mediated signals are involved in many important aspects of development of the mammalian cerebral cortex. How Wnts interact with their modulators in cortical development is still unclear. Here, we show that Wnt7a and secreted frizzled-related protein 1 (Sfrp1), a soluble modulator of Wnts, are co-expressed in mouse embryonic cortical neural progenitors (NPs). Knockout of Wnt7a in mice causes microcephaly due to reduced NP population and neurogenesis, and Sfrp1 has an opposing effect compared to Wnt7a. Similar to Dkk1, Sfrp1 decreases the Wnt1 and Wnt7a activity in vitro. Our results suggest that Wnt7a and Sfrp1 play opposite roles to ensure proper NP progeny in the developing cortex. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 32% |
Student > Doctoral Student | 4 | 16% |
Student > Master | 2 | 8% |
Other | 1 | 4% |
Student > Bachelor | 1 | 4% |
Other | 4 | 16% |
Unknown | 5 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 20% |
Neuroscience | 4 | 16% |
Nursing and Health Professions | 2 | 8% |
Agricultural and Biological Sciences | 2 | 8% |
Unspecified | 1 | 4% |
Other | 4 | 16% |
Unknown | 7 | 28% |