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Attention Score in Context
| Title |
A-Type KV Channels in Dorsal Root Ganglion Neurons: Diversity, Function, and Dysfunction
|
|---|---|
| Published in |
Frontiers in Molecular Neuroscience, August 2018
|
| DOI | 10.3389/fnmol.2018.00253 |
| Pubmed ID | |
| Authors |
Benjamin M. Zemel, David M. Ritter, Manuel Covarrubias, Tanziyah Muqeem |
| Abstract |
A-type voltage-gated potassium (Kv) channels are major regulators of neuronal excitability that have been mainly characterized in the central nervous system. By contrast, there is a paucity of knowledge about the molecular physiology of these Kv channels in the peripheral nervous system, including highly specialized and heterogenous dorsal root ganglion (DRG) neurons. Although all A-type Kv channels display pore-forming subunits with similar structural properties and fast inactivation, their voltage-, and time-dependent properties and modulation are significantly different. These differences ultimately determine distinct physiological roles of diverse A-type Kv channels, and how their dysfunction might contribute to neurological disorders. The importance of A-type Kv channels in DRG neurons is highlighted by recent studies that have linked their dysfunction to persistent pain sensitization. Here, we review the molecular neurophysiology of A-type Kv channels with an emphasis on those that have been identified and investigated in DRG nociceptors (Kv1.4, Kv3.4, and Kv4s). Also, we discuss evidence implicating these Kv channels in neuropathic pain resulting from injury, and present a perspective of outstanding challenges that must be tackled in order to discover novel treatments for intractable pain disorders. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 99 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 28% |
| Researcher | 12 | 12% |
| Student > Master | 10 | 10% |
| Student > Bachelor | 7 | 7% |
| Student > Doctoral Student | 5 | 5% |
| Other | 9 | 9% |
| Unknown | 28 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 32 | 32% |
| Biochemistry, Genetics and Molecular Biology | 13 | 13% |
| Agricultural and Biological Sciences | 7 | 7% |
| Medicine and Dentistry | 5 | 5% |
| Engineering | 4 | 4% |
| Other | 5 | 5% |
| Unknown | 33 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2018.
All research outputs
#21,709,675
of 24,226,848 outputs
Outputs from Frontiers in Molecular Neuroscience
#2,725
of 3,158 outputs
Outputs of similar age
#292,492
of 334,616 outputs
Outputs of similar age from Frontiers in Molecular Neuroscience
#112
of 122 outputs
Altmetric has tracked 24,226,848 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,158 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,616 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 122 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.