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The best-laid plans go oft awry: synaptogenic growth factor signaling in neuropsychiatric disease

Overview of attention for article published in Frontiers in Synaptic Neuroscience, March 2014
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Title
The best-laid plans go oft awry: synaptogenic growth factor signaling in neuropsychiatric disease
Published in
Frontiers in Synaptic Neuroscience, March 2014
DOI 10.3389/fnsyn.2014.00004
Pubmed ID
Authors

Aislinn J. Williams, Hisashi Umemori

Abstract

Growth factors play important roles in synapse formation. Mouse models of neuropsychiatric diseases suggest that defects in synaptogenic growth factors, their receptors, and signaling pathways can lead to disordered neural development and various behavioral phenotypes, including anxiety, memory problems, and social deficits. Genetic association studies in humans have found evidence for similar relationships between growth factor signaling pathways and neuropsychiatric phenotypes. Accumulating data suggest that dysfunction in neuronal circuitry, caused by defects in growth factor-mediated synapse formation, contributes to the susceptibility to multiple neuropsychiatric diseases, including epilepsy, autism, and disorders of thought and mood (e.g., schizophrenia and bipolar disorder, respectively). In this review, we will focus on how specific synaptogenic growth factors and their downstream signaling pathways might be involved in the development of neuropsychiatric diseases.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 1%
Unknown 86 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 15%
Student > Ph. D. Student 11 13%
Student > Master 11 13%
Student > Bachelor 8 9%
Student > Doctoral Student 7 8%
Other 17 20%
Unknown 20 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 18%
Psychology 11 13%
Medicine and Dentistry 10 11%
Neuroscience 7 8%
Biochemistry, Genetics and Molecular Biology 6 7%
Other 17 20%
Unknown 20 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2014.
All research outputs
#20,231,392
of 22,757,090 outputs
Outputs from Frontiers in Synaptic Neuroscience
#363
of 408 outputs
Outputs of similar age
#208,848
of 242,920 outputs
Outputs of similar age from Frontiers in Synaptic Neuroscience
#6
of 6 outputs
Altmetric has tracked 22,757,090 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 408 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,920 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.