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The Shank3 Interaction Partner ProSAPiP1 Regulates Postsynaptic SPAR Levels and the Maturation of Dendritic Spines in Hippocampal Neurons

Overview of attention for article published in Frontiers in Synaptic Neuroscience, May 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

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1 news outlet
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2 X users
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1 Facebook page

Citations

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7 Dimensions

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25 Mendeley
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Title
The Shank3 Interaction Partner ProSAPiP1 Regulates Postsynaptic SPAR Levels and the Maturation of Dendritic Spines in Hippocampal Neurons
Published in
Frontiers in Synaptic Neuroscience, May 2016
DOI 10.3389/fnsyn.2016.00013
Pubmed ID
Authors

Dominik Reim, Tobias M. Weis, Sonja Halbedl, Jan Philipp Delling, Andreas M. Grabrucker, Tobias M. Boeckers, Michael J. Schmeisser

Abstract

The postsynaptic density or PSD is a submembranous compartment containing a wide array of proteins that contribute to both morphology and function of excitatory glutamatergic synapses. In this study, we have analyzed functional aspects of the Fezzin ProSAP-interacting protein 1 (ProSAPiP1), an interaction partner of the well-known PSD proteins Shank3 and SPAR. Using lentiviral-mediated overexpression and knockdown of ProSAPiP1, we found that this protein is dispensable for the formation of both pre- and postsynaptic specializations per se. We further show that ProSAPiP1 regulates SPAR levels at the PSD and the maturation of dendritic spines. In line with previous findings on the ProSAPiP1 homolog PSD-Zip70, we conclude that Fezzins essentially contribute to the maturation of excitatory spine synapses.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 28%
Student > Master 4 16%
Student > Bachelor 4 16%
Student > Doctoral Student 3 12%
Researcher 3 12%
Other 2 8%
Unknown 2 8%
Readers by discipline Count As %
Neuroscience 8 32%
Agricultural and Biological Sciences 7 28%
Biochemistry, Genetics and Molecular Biology 5 20%
Medicine and Dentistry 2 8%
Psychology 1 4%
Other 0 0%
Unknown 2 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2017.
All research outputs
#3,076,784
of 22,873,031 outputs
Outputs from Frontiers in Synaptic Neuroscience
#60
of 413 outputs
Outputs of similar age
#55,495
of 334,086 outputs
Outputs of similar age from Frontiers in Synaptic Neuroscience
#1
of 11 outputs
Altmetric has tracked 22,873,031 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 413 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,086 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.