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Memory Synapses Are Defined by Distinct Molecular Complexes: A Proposal

Overview of attention for article published in Frontiers in Synaptic Neuroscience, April 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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Title
Memory Synapses Are Defined by Distinct Molecular Complexes: A Proposal
Published in
Frontiers in Synaptic Neuroscience, April 2018
DOI 10.3389/fnsyn.2018.00005
Pubmed ID
Authors

Wayne S. Sossin

Abstract

Synapses are diverse in form and function. While there are strong evidential and theoretical reasons for believing that memories are stored at synapses, the concept of a specialized "memory synapse" is rarely discussed. Here, we review the evidence that memories are stored at the synapse and consider the opposing possibilities. We argue that if memories are stored in an active fashion at synapses, then these memory synapses must have distinct molecular complexes that distinguish them from other synapses. In particular, examples from Aplysia sensory-motor neuron synapses and synapses on defined engram neurons in rodent models are discussed. Specific hypotheses for molecular complexes that define memory synapses are presented, including persistently active kinases, transmitter receptor complexes and trans-synaptic adhesion proteins.

X Demographics

X Demographics

The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 51 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 24%
Student > Ph. D. Student 9 18%
Student > Bachelor 7 14%
Student > Master 7 14%
Student > Doctoral Student 4 8%
Other 5 10%
Unknown 7 14%
Readers by discipline Count As %
Neuroscience 23 45%
Agricultural and Biological Sciences 7 14%
Biochemistry, Genetics and Molecular Biology 4 8%
Psychology 4 8%
Medicine and Dentistry 2 4%
Other 5 10%
Unknown 6 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2022.
All research outputs
#3,411,619
of 24,804,602 outputs
Outputs from Frontiers in Synaptic Neuroscience
#67
of 442 outputs
Outputs of similar age
#66,470
of 334,340 outputs
Outputs of similar age from Frontiers in Synaptic Neuroscience
#3
of 8 outputs
Altmetric has tracked 24,804,602 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 442 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,340 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.