Title |
The Age of Enlightenment: Evolving Opportunities in Brain Research Through Optical Manipulation of Neuronal Activity
|
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Published in |
Frontiers in Systems Neuroscience, January 2011
|
DOI | 10.3389/fnsys.2011.00095 |
Pubmed ID | |
Authors |
Jason Jerome, Detlef H. Heck |
Abstract |
Optical manipulation of neuronal activity has rapidly developed into the most powerful and widely used approach to study mechanisms related to neuronal connectivity over a range of scales. Since the early use of single site uncaging to map network connectivity, rapid technological development of light modulation techniques has added important new options, such as fast scanning photostimulation, massively parallel control of light stimuli, holographic uncaging, and two-photon stimulation techniques. Exciting new developments in optogenetics complement neurotransmitter uncaging techniques by providing cell-type specificity and in vivo usability, providing optical access to the neural substrates of behavior. Here we review the rapid evolution of methods for the optical manipulation of neuronal activity, emphasizing crucial recent developments. |
X Demographics
Geographical breakdown
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Spain | 1 | 50% |
Mexico | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 3 | 6% |
Italy | 1 | 2% |
Germany | 1 | 2% |
United Kingdom | 1 | 2% |
India | 1 | 2% |
Unknown | 45 | 87% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 19 | 37% |
Student > Ph. D. Student | 11 | 21% |
Student > Bachelor | 4 | 8% |
Other | 4 | 8% |
Student > Postgraduate | 3 | 6% |
Other | 7 | 13% |
Unknown | 4 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 21 | 40% |
Neuroscience | 8 | 15% |
Engineering | 6 | 12% |
Medicine and Dentistry | 4 | 8% |
Computer Science | 2 | 4% |
Other | 8 | 15% |
Unknown | 3 | 6% |