Title |
Histamine H3 receptor antagonists/inverse agonists on cognitive and motor processes: relevance to Alzheimer's disease, ADHD, schizophrenia, and drug abuse
|
---|---|
Published in |
Frontiers in Systems Neuroscience, January 2012
|
DOI | 10.3389/fnsys.2012.00072 |
Pubmed ID | |
Authors |
Divya Vohora, Malay Bhowmik |
Abstract |
Histamine H3 receptor (H3R) antagonists/inverse agonists possess potential to treat diverse disease states of the central nervous system (CNS). Cognitive dysfunction and motor impairments are the hallmark of multifarious neurodegenerative and/or psychiatric disorders. This review presents the various neurobiological/neurochemical evidences available so far following H3R antagonists in the pathophysiology of Alzheimer's disease (AD), attention-deficit hyperactivity disorder (ADHD), schizophrenia, and drug abuse each of which is accompanied by deficits of some aspects of cognitive and/or motor functions. Whether the H3R inverse agonism modulates the neurochemical basis underlying the disease condition or affects only the cognitive/motor component of the disease process is discussed with the aim to provide a rationale for their use in diverse disease states that are interlinked and are accompanied by some common motor, cognitive and attentional deficits. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 13% |
Switzerland | 1 | 13% |
Unknown | 6 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 88% |
Scientists | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | <1% |
Brazil | 1 | <1% |
United Kingdom | 1 | <1% |
Mexico | 1 | <1% |
Spain | 1 | <1% |
Unknown | 122 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 16% |
Researcher | 19 | 15% |
Student > Bachelor | 19 | 15% |
Student > Master | 18 | 14% |
Other | 6 | 5% |
Other | 18 | 14% |
Unknown | 27 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 14% |
Agricultural and Biological Sciences | 18 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 15 | 12% |
Neuroscience | 11 | 9% |
Biochemistry, Genetics and Molecular Biology | 8 | 6% |
Other | 22 | 17% |
Unknown | 35 | 28% |