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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Subthalamic nucleus long-range synchronization—an independent hallmark of human Parkinson's disease
|
|---|---|
| Published in |
Frontiers in Systems Neuroscience, January 2013
|
| DOI | 10.3389/fnsys.2013.00079 |
| Pubmed ID | |
| Authors |
Shay Moshel, Reuben R. Shamir, Aeyal Raz, Fernando R. de Noriega, Renana Eitan, Hagai Bergman, Zvi Israel |
| Abstract |
Beta-band synchronous oscillations in the dorsolateral region of the subthalamic nucleus (STN) of human patients with Parkinson's disease (PD) have been frequently reported. However, the correlation between STN oscillations and synchronization has not been thoroughly explored. The simultaneous recordings of 2390 multi-unit pairs recorded by two parallel microelectrodes (separated by fixed distance of 2 mm, n = 72 trajectories with two electrode tracks >4 mm STN span) in 57 PD patients undergoing STN deep brain stimulation surgery were analyzed. Automatic procedures were utilized to divide the STN into dorsolateral oscillatory and ventromedial non-oscillatory regions, and to quantify the intensity of STN oscillations and synchronicity. Finally, the synchronicity of simultaneously vs. non-simultaneously recorded pairs were compared using a shuffling procedure. Synchronization was observed predominately in the beta range and only between multi-unit pairs in the dorsolateral oscillatory region (n = 615). In paired recordings between sites in the dorsolateral and ventromedial (n = 548) and ventromedial-ventromedial region pairs (n = 1227), no synchronization was observed. Oscillation and synchronicity intensity decline along the STN dorsolateral-ventromedial axis suggesting a fuzzy border between the STN regions. Synchronization strength was significantly correlated to the oscillation power, but synchronization was no longer observed following shuffling. We conclude that STN long-range beta oscillatory synchronization is due to increased neuronal coupling in the Parkinsonian brain and does not merely reflect the outcome of oscillations at similar frequency. The neural synchronization in the dorsolateral (probably the motor domain) STN probably augments the pathological changes in firing rate and patterns of subthalamic neurons in PD patients. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 4 | 5% |
| United States | 1 | 1% |
| China | 1 | 1% |
| Italy | 1 | 1% |
| Unknown | 67 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 22% |
| Student > Ph. D. Student | 11 | 15% |
| Student > Master | 8 | 11% |
| Student > Doctoral Student | 6 | 8% |
| Professor > Associate Professor | 6 | 8% |
| Other | 13 | 18% |
| Unknown | 14 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 16 | 22% |
| Medicine and Dentistry | 15 | 20% |
| Agricultural and Biological Sciences | 9 | 12% |
| Engineering | 6 | 8% |
| Unspecified | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 20 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2013.
All research outputs
#18,355,685
of 22,733,113 outputs
Outputs from Frontiers in Systems Neuroscience
#1,128
of 1,339 outputs
Outputs of similar age
#218,085
of 280,774 outputs
Outputs of similar age from Frontiers in Systems Neuroscience
#75
of 95 outputs
Altmetric has tracked 22,733,113 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,339 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,774 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.