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Plasticity of cerebellar Purkinje cells in behavioral training of body balance control

Overview of attention for article published in Frontiers in Systems Neuroscience, August 2015
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Title
Plasticity of cerebellar Purkinje cells in behavioral training of body balance control
Published in
Frontiers in Systems Neuroscience, August 2015
DOI 10.3389/fnsys.2015.00113
Pubmed ID
Authors

Ray X. Lee, Jian-Jia Huang, Chiming Huang, Meng-Li Tsai, Chen-Tung Yen

Abstract

Neural responses to sensory inputs caused by self-generated movements (reafference) and external passive stimulation (exafference) differ in various brain regions. The ability to differentiate such sensory information can lead to movement execution with better accuracy. However, how sensory responses are adjusted in regard to this distinguishability during motor learning is still poorly understood. The cerebellum has been hypothesized to analyze the functional significance of sensory information during motor learning, and is thought to be a key region of reafference computation in the vestibular system. In this study, we investigated Purkinje cell (PC) spike trains as cerebellar cortical output when rats learned to balance on a suspended dowel. Rats progressively reduced the amplitude of body swing and made fewer foot slips during a 5-min balancing task. Both PC simple (SSs; 17 of 26) and complex spikes (CSs; 7 of 12) were found to code initially on the angle of the heads with respect to a fixed reference. Using periods with comparable degrees of movement, we found that such SS coding of information in most PCs (10 of 17) decreased rapidly during balance learning. In response to unexpected perturbations and under anesthesia, SS coding capability of these PCs recovered. By plotting SS and CS firing frequencies over 15-s time windows in double-logarithmic plots, a negative correlation between SS and CS was found in awake, but not anesthetized, rats. PCs with prominent SS coding attenuation during motor learning showed weaker SS-CS correlation. Hence, we demonstrate that neural plasticity for filtering out sensory reafference from active motion occurs in the cerebellar cortex in rats during balance learning. SS-CS interaction may contribute to this rapid plasticity as a form of receptive field plasticity in the cerebellar cortex between two receptive maps of sensory inputs from the external world and of efference copies from the will center for volitional movements.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 41 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 24%
Student > Master 10 24%
Researcher 7 17%
Student > Doctoral Student 4 10%
Student > Postgraduate 3 7%
Other 2 5%
Unknown 6 14%
Readers by discipline Count As %
Neuroscience 13 31%
Agricultural and Biological Sciences 8 19%
Psychology 5 12%
Medicine and Dentistry 5 12%
Sports and Recreations 3 7%
Other 2 5%
Unknown 6 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2015.
All research outputs
#14,819,430
of 22,818,766 outputs
Outputs from Frontiers in Systems Neuroscience
#888
of 1,342 outputs
Outputs of similar age
#145,339
of 264,147 outputs
Outputs of similar age from Frontiers in Systems Neuroscience
#21
of 38 outputs
Altmetric has tracked 22,818,766 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,342 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,147 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.