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Neural plasticity in hypocretin neurons: the basis of hypocretinergic regulation of physiological and behavioral functions in animals

Overview of attention for article published in Frontiers in Systems Neuroscience, October 2015
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  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • Average Attention Score compared to outputs of the same age and source

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Title
Neural plasticity in hypocretin neurons: the basis of hypocretinergic regulation of physiological and behavioral functions in animals
Published in
Frontiers in Systems Neuroscience, October 2015
DOI 10.3389/fnsys.2015.00142
Pubmed ID
Authors

Xiao-Bing Gao, Gretchen Hermes

Abstract

The neuronal system that resides in the perifornical and lateral hypothalamus (Pf/LH) and synthesizes the neuropeptide hypocretin/orexin participates in critical brain functions across species from fish to human. The hypocretin system regulates neural activity responsible for daily functions (such as sleep/wake homeostasis, energy balance, appetite, etc.) and long-term behavioral changes (such as reward seeking and addiction, stress response, etc.) in animals. The most recent evidence suggests that the hypocretin system undergoes substantial plastic changes in response to both daily fluctuations (such as food intake and sleep-wake regulation) and long-term changes (such as cocaine seeking) in neuronal activity in the brain. The understanding of these changes in the hypocretin system is essential in addressing the role of the hypocretin system in normal physiological functions and pathological conditions in animals and humans. In this review, the evidence demonstrating that neural plasticity occurs in hypocretin-containing neurons in the Pf/LH will be presented and possible physiological, behavioral, and mental health implications of these findings will be discussed.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 2%
Uruguay 1 2%
China 1 2%
Unknown 44 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 23%
Student > Bachelor 7 15%
Researcher 6 13%
Professor > Associate Professor 3 6%
Student > Master 3 6%
Other 7 15%
Unknown 10 21%
Readers by discipline Count As %
Neuroscience 15 32%
Agricultural and Biological Sciences 7 15%
Medicine and Dentistry 5 11%
Psychology 3 6%
Immunology and Microbiology 2 4%
Other 4 9%
Unknown 11 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2015.
All research outputs
#12,644,424
of 22,830,751 outputs
Outputs from Frontiers in Systems Neuroscience
#644
of 1,342 outputs
Outputs of similar age
#121,801
of 283,225 outputs
Outputs of similar age from Frontiers in Systems Neuroscience
#21
of 40 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,342 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,225 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.