Title |
Hydroxytyrosol and Potential Uses in Cardiovascular Diseases, Cancer, and AIDS
|
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Published in |
Frontiers in Nutrition, October 2014
|
DOI | 10.3389/fnut.2014.00018 |
Pubmed ID | |
Authors |
Cristina Vilaplana-Pérez, David Auñón, Libia A. García-Flores, Angel Gil-Izquierdo |
Abstract |
Hydroxytyrosol is one of the main phenolic components of olive oil. It is present in the fruit and leaf of the olive (Olea europaea L.). During the past decades, it has been well documented that this phenolic compound has health benefits and a protective action has been found in preclinical studies against several diseases. Here, we review its bioavailability in human beings and several assays showing significant results related with cardiovascular diseases, cancer, and acquired immunodeficiency syndrome (AIDS). Mechanisms of action include potent anti-oxidant and anti-inflammatory effects, among others. The importance of hydroxytyrosol in protection of low-density lipoproteins and consequently its implication in the reduction of cardiovascular disease risk has been highlighted by the European Food Safety Authority, concluding that 5 mg of hydroxytyrosol and its derivatives should be consumed daily to reach this effect at physiological level. We discuss the potential uses of this compound in supplements, nutraceutic foods, or topical formulations in the disease risk reduction. Finally, we conclude that more studies are needed to sustain or reject many other health claims not yet fully documented and to validate these newly available hydroxytyrosol-based products, because it seems to be a good candidate to reduce the risk of diseases mentioned. |
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Switzerland | 2 | 7% |
Spain | 2 | 7% |
United States | 1 | 4% |
Serbia | 1 | 4% |
Canada | 1 | 4% |
Ireland | 1 | 4% |
Unknown | 14 | 50% |
Demographic breakdown
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Practitioners (doctors, other healthcare professionals) | 4 | 14% |
Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Poland | 1 | <1% |
Unknown | 196 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 34 | 17% |
Student > Master | 29 | 15% |
Student > Ph. D. Student | 21 | 11% |
Student > Bachelor | 20 | 10% |
Student > Doctoral Student | 11 | 6% |
Other | 30 | 15% |
Unknown | 53 | 27% |
Readers by discipline | Count | As % |
---|---|---|
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Biochemistry, Genetics and Molecular Biology | 22 | 11% |
Chemistry | 22 | 11% |
Medicine and Dentistry | 14 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 5% |
Other | 38 | 19% |
Unknown | 63 | 32% |