Title |
Anticancer Molecular Mechanisms of Resveratrol
|
---|---|
Published in |
Frontiers in Nutrition, April 2016
|
DOI | 10.3389/fnut.2016.00008 |
Pubmed ID | |
Authors |
Elena M. Varoni, Alfredo Fabrizio Lo Faro, Javad Sharifi-Rad, Marcello Iriti |
Abstract |
Resveratrol is a pleiotropic phytochemical belonging to the stilbene family. Though it is only significantly present in grape products, a huge amount of preclinical studies investigated its anticancer properties in a plethora of cellular and animal models. Molecular mechanisms of resveratrol involved signaling pathways related to extracellular growth factors and receptor tyrosine kinases; formation of multiprotein complexes and cell metabolism; cell proliferation and genome instability; cytoplasmic tyrosine kinase signaling (cytokine, integrin, and developmental pathways); signal transduction by the transforming growth factor-β super-family; apoptosis and inflammation; and immune surveillance and hormone signaling. Resveratrol also showed a promising role to counteract multidrug resistance: in adjuvant therapy, associated with 5-fluoruracyl and cisplatin, resveratrol had additive and/or synergistic effects increasing the chemosensitization of cancer cells. Resveratrol, by acting on diverse mechanisms simultaneously, has been emphasized as a promising, multi-target, anticancer agent, relevant in both cancer prevention and treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 5 | 25% |
Canada | 2 | 10% |
India | 2 | 10% |
Italy | 1 | 5% |
Colombia | 1 | 5% |
Austria | 1 | 5% |
Switzerland | 1 | 5% |
Unknown | 7 | 35% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 35% |
Scientists | 6 | 30% |
Practitioners (doctors, other healthcare professionals) | 5 | 25% |
Science communicators (journalists, bloggers, editors) | 2 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 328 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 47 | 14% |
Student > Master | 42 | 13% |
Student > Bachelor | 38 | 12% |
Researcher | 36 | 11% |
Student > Doctoral Student | 17 | 5% |
Other | 44 | 13% |
Unknown | 104 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 60 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 42 | 13% |
Agricultural and Biological Sciences | 38 | 12% |
Medicine and Dentistry | 26 | 8% |
Chemistry | 14 | 4% |
Other | 34 | 10% |
Unknown | 114 | 35% |