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Endoplasmic reticulum involvement in yeast cell death

Overview of attention for article published in Frontiers in oncology, January 2012
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Title
Endoplasmic reticulum involvement in yeast cell death
Published in
Frontiers in oncology, January 2012
DOI 10.3389/fonc.2012.00087
Pubmed ID
Authors

O. P. Nicanor Austriaco

Abstract

Yeast cells undergo programed cell death (PCD) with characteristic markers associated with apoptosis in mammalian cells including chromatin breakage, nuclear fragmentation, reactive oxygen species generation, and metacaspase activation. Though significant research has focused on mitochondrial involvement in this phenomenon, more recent work with both Saccharomyces cerevisiae and Schizosaccharomyces pombe has also implicated the endoplasmic reticulum (ER) in yeast PCD. This minireview provides an overview of ER stress-associated cell death (ER-SAD) in yeast. It begins with a description of ER structure and function in yeast before moving to a discussion of ER-SAD in both mammalian and yeast cells. Three examples of yeast cell death associated with the ER will be highlighted here including inositol starvation, lipid toxicity, and the inhibition of N-glycosylation. It closes by suggesting ways to further examine the involvement of the ER in yeast cell death.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 1%
Germany 1 1%
Unknown 65 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 25%
Student > Master 11 16%
Researcher 10 15%
Student > Bachelor 8 12%
Student > Doctoral Student 2 3%
Other 9 13%
Unknown 10 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 40%
Biochemistry, Genetics and Molecular Biology 21 31%
Medicine and Dentistry 4 6%
Unspecified 1 1%
Chemical Engineering 1 1%
Other 2 3%
Unknown 11 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2012.
All research outputs
#22,778,604
of 25,394,764 outputs
Outputs from Frontiers in oncology
#15,927
of 22,440 outputs
Outputs of similar age
#228,625
of 250,240 outputs
Outputs of similar age from Frontiers in oncology
#100
of 161 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,440 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 161 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.