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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Interactions between epigenetics and metabolism in cancers
|
|---|---|
| Published in |
Frontiers in oncology, January 2012
|
| DOI | 10.3389/fonc.2012.00163 |
| Pubmed ID | |
| Authors |
Jihye Yun, Jared L. Johnson, Christin L. Hanigan, Jason W. Locasale |
| Abstract |
Cancer progression is accompanied by widespread transcriptional changes and metabolic alterations. While it is widely accepted that the origin of cancer can be traced to the mutations that accumulate over time, relatively recent evidence favors a similarly fundamental role for alterations in the epigenome during tumorigenesis. Changes in epigenetics that arise from post-translational modifications of histones and DNA are exploited by cancer cells to upregulate and/or downregulate the expression levels of oncogenes and tumor suppressors, respectively. Although the mechanisms behind these modifications, in particular how they lead to gene silencing and activation, are still being understood, most of the enzymatic machinery of epigenetics require metabolites as substrates or cofactors. As a result, their activities can be influenced by the metabolic state of the cell. The purpose of this review is to give an overview of cancer epigenetics and metabolism and provide examples of where they converge. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 33% |
| Australia | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Australia | 1 | <1% |
| Czechia | 1 | <1% |
| Brazil | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Unknown | 164 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 38 | 22% |
| Student > Ph. D. Student | 37 | 22% |
| Student > Master | 22 | 13% |
| Student > Bachelor | 20 | 12% |
| Student > Doctoral Student | 6 | 4% |
| Other | 20 | 12% |
| Unknown | 28 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 62 | 36% |
| Biochemistry, Genetics and Molecular Biology | 42 | 25% |
| Medicine and Dentistry | 13 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Chemistry | 5 | 3% |
| Other | 10 | 6% |
| Unknown | 34 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 November 2012.
All research outputs
#15,755,393
of 25,394,764 outputs
Outputs from Frontiers in oncology
#4,981
of 22,440 outputs
Outputs of similar age
#161,732
of 250,240 outputs
Outputs of similar age from Frontiers in oncology
#51
of 161 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,440 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,240 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 161 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.