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The promise of the anti-idiotype concept

Overview of attention for article published in Frontiers in oncology, January 2012
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Title
The promise of the anti-idiotype concept
Published in
Frontiers in oncology, January 2012
DOI 10.3389/fonc.2012.00196
Pubmed ID
Authors

Thomas Kieber-Emmons, Bejatohlah Monzavi-Karbassi, Anastas Pashov, Somdutta Saha, Ramachandran Murali, Heinz Kohler

Abstract

A basic tenet of antibody-based immunity is their specificity to antigenic determinates from foreign pathogen products to abnormal cellular components such as in cancer. However, an antibody has the potential to bind to more than one determinate, be it an antigen or another antibody. These observations led to the idiotype network theory (INT) to explain immune regulation, which has wax and waned in enthusiasm over the years. A truer measure of the impact of the INT is in terms of the ideas that now form the mainstay of immunological research and whose roots are spawned from the promise of the anti-idiotype concept. Among the applications of the INT is understanding the structural implications of the antibody-mediated network that has the potential for innovation in terms of rational design of reagents with biological, chemical, and pharmaceutical applications that underlies concepts of reverse immunology which is highlighted herein.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 20%
Student > Ph. D. Student 8 18%
Student > Master 7 16%
Student > Bachelor 5 11%
Other 3 7%
Other 4 9%
Unknown 9 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 27%
Medicine and Dentistry 7 16%
Agricultural and Biological Sciences 5 11%
Immunology and Microbiology 5 11%
Engineering 2 4%
Other 3 7%
Unknown 11 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2012.
All research outputs
#22,758,309
of 25,371,288 outputs
Outputs from Frontiers in oncology
#15,917
of 22,414 outputs
Outputs of similar age
#228,476
of 250,087 outputs
Outputs of similar age from Frontiers in oncology
#100
of 161 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,414 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,087 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 161 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.