Title |
The Tumor Microenvironment: A Pitch for Multiple Players
|
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Published in |
Frontiers in oncology, January 2013
|
DOI | 10.3389/fonc.2013.00090 |
Pubmed ID | |
Authors |
Giovanna Schiavoni, Lucia Gabriele, Fabrizio Mattei |
Abstract |
The cancer microenvironment may be conceptually regarded as a pitch where the main players are resident and non-resident cellular components, each covering a defined role and interconnected by a complex network of soluble mediators. The crosstalk between these cells and the tumor cells within this environment crucially determines the fate of tumor progression. Immune cells that infiltrate the tumor bed are transported there by blood circulation and exert a variety of effects, either counteracting or favoring tumor outgrowth. Here, we review and discuss the multiple populations composing the tumor bed, with special focus on immune cells subsets that positively or negatively dictate neoplastic progression. In this scenario, the contribution of cancer stem cells within the tumor microenvironment will also be discussed. Finally, we illustrate recent advances on new integrated approaches to investigate the tumor microenvironment in vitro. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Central African Republic | 1 | 50% |
Switzerland | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 1% |
Portugal | 1 | <1% |
Italy | 1 | <1% |
Australia | 1 | <1% |
United Kingdom | 1 | <1% |
United States | 1 | <1% |
Unknown | 129 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 26 | 19% |
Researcher | 25 | 18% |
Student > Bachelor | 14 | 10% |
Student > Master | 14 | 10% |
Other | 13 | 10% |
Other | 14 | 10% |
Unknown | 30 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 31 | 23% |
Medicine and Dentistry | 24 | 18% |
Biochemistry, Genetics and Molecular Biology | 22 | 16% |
Immunology and Microbiology | 11 | 8% |
Veterinary Science and Veterinary Medicine | 4 | 3% |
Other | 7 | 5% |
Unknown | 37 | 27% |