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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Immunosuppressive Microenvironment in Neuroblastoma
|
|---|---|
| Published in |
Frontiers in oncology, January 2013
|
| DOI | 10.3389/fonc.2013.00167 |
| Pubmed ID | |
| Authors |
Vito Pistoia, Fabio Morandi, Giovanna Bianchi, Annalisa Pezzolo, Ignazia Prigione, Lizzia Raffaghello |
| Abstract |
According to the cancer immunoediting model, the interplay between tumor cells and the host immune system is crucial for the control of tumor growth. NB is a pediatric tumor that presents with metastatic disease at diagnosis in about 50% of the cases, the majority of which have poor prognosis. In this Review article, immune escape pathways adopted by human neuroblastoma (NB) cells are reviewed. These include intrinsic defects of tumor cells such impaired expression of the HLA class I related antigen processing machinery and functional alterations of the tumor microenvironment (TM) induced by NB cell-derived immunosuppressive molecules as MICA and HLA-G. Finally, examples of therapeutic interventions targeting the TM are discussed to emphasize the concept that successful cancer treatment may be achieved using this strategy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Spain | 1 | 1% |
| Unknown | 88 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 17% |
| Researcher | 14 | 16% |
| Student > Bachelor | 13 | 14% |
| Student > Master | 12 | 13% |
| Student > Doctoral Student | 6 | 7% |
| Other | 13 | 14% |
| Unknown | 17 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 30% |
| Biochemistry, Genetics and Molecular Biology | 18 | 20% |
| Agricultural and Biological Sciences | 12 | 13% |
| Immunology and Microbiology | 8 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 7 | 8% |
| Unknown | 16 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2013.
All research outputs
#22,760,732
of 25,374,917 outputs
Outputs from Frontiers in oncology
#15,919
of 22,416 outputs
Outputs of similar age
#258,419
of 289,007 outputs
Outputs of similar age from Frontiers in oncology
#194
of 328 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,416 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 289,007 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 328 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.