Title |
Prognostic and Predictive Biomarkers in Adult and Pediatric Gliomas: Toward Personalized Treatment
|
---|---|
Published in |
Frontiers in oncology, March 2014
|
DOI | 10.3389/fonc.2014.00047 |
Pubmed ID | |
Authors |
Harry R. Haynes, Sandra Camelo-Piragua, Kathreena M. Kurian |
Abstract |
It is increasingly clear that both adult and pediatric glial tumor entities represent collections of neoplastic lesions, each with individual pathological molecular events and treatment responses. In this review, we discuss the current prognostic biomarkers validated for clinical use or with future clinical validity for gliomas. Accurate prognostication is crucial for managing patients as treatments may be associated with high morbidity and the benefits of high risk interventions must be judged by the treating clinicians. We also review biomarkers with predictive validity, which may become clinically relevant with the development of targeted therapies for adult and pediatric gliomas. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Switzerland | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Ukraine | 1 | 1% |
Czechia | 1 | 1% |
Unknown | 78 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 19% |
Student > Master | 13 | 16% |
Student > Ph. D. Student | 12 | 15% |
Student > Bachelor | 11 | 14% |
Other | 7 | 9% |
Other | 9 | 11% |
Unknown | 14 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 28% |
Biochemistry, Genetics and Molecular Biology | 13 | 16% |
Agricultural and Biological Sciences | 13 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Chemistry | 3 | 4% |
Other | 10 | 12% |
Unknown | 16 | 20% |