Title |
Biomarkers That Currently Affect Clinical Practice in Lung Cancer: EGFR, ALK, MET, ROS-1, and KRAS
|
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Published in |
Frontiers in oncology, August 2014
|
DOI | 10.3389/fonc.2014.00204 |
Pubmed ID | |
Authors |
Grzegorz J. Korpanty, Donna M. Graham, Mark D. Vincent, Natasha B. Leighl |
Abstract |
Lung cancer remains the most lethal malignancy in the world. Despite improvements in surgical treatment, systemic therapy, and radiotherapy, the 5-year survival rate for all patients diagnosed with lung cancer remains between 15 and 20%. Newer therapeutic strategies rely on specific molecular alterations, or biomarkers, that provide opportunities for a personalized approach to specific patient populations. Classification of lung cancer is becoming increasingly focused on these biomarkers, which renders the term "non-small cell lung" cancer less clinically useful. Non-small cell lung cancer is now recognized as a complex malignancy and its molecular and genomic diversity allows for patient-centered treatment options. Here, we review advances in targeted treatment of lung adenocarcinoma with respect to five clinically relevant biomarkers - EGFR, ALK, MET, ROS-1, and KRAS. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 33% |
United Kingdom | 1 | 11% |
Italy | 1 | 11% |
Unknown | 4 | 44% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 67% |
Practitioners (doctors, other healthcare professionals) | 2 | 22% |
Scientists | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Austria | 1 | <1% |
Unknown | 188 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 34 | 18% |
Student > Master | 31 | 16% |
Researcher | 21 | 11% |
Student > Bachelor | 19 | 10% |
Student > Postgraduate | 18 | 10% |
Other | 37 | 20% |
Unknown | 29 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 49 | 26% |
Biochemistry, Genetics and Molecular Biology | 42 | 22% |
Agricultural and Biological Sciences | 32 | 17% |
Chemistry | 5 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
Other | 23 | 12% |
Unknown | 33 | 17% |