Title |
The Management of Brain Metastases in Non-Small Cell Lung Cancer
|
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Published in |
Frontiers in oncology, September 2014
|
DOI | 10.3389/fonc.2014.00248 |
Pubmed ID | |
Authors |
Scott Owen, Luis Souhami |
Abstract |
Brain metastases (BM) are a common and lethal complication of non-small cell lung cancer (NSCLC), which portend a poor prognosis. In addition, their management implies several challenges including preservation of neurological and neurocognitive function during surgery or radiation-therapy, minimizing iatrogenic complications of supportive medications, and optimizing drug delivery across the blood-brain barrier. Despite these challenges, advancements in combined modality approaches can deliver hope of improved overall survival and quality of life for a subset of NSCLC patients with BM. Moreover, new drugs harnessing our greater understanding of tumor biology promise to build on this hope. In this mini-review, we revised the management of BM in NSCLC including advancements in neurosurgery, radiation therapy, as well as systemic and supportive therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 1% |
Unknown | 87 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 13 | 15% |
Student > Bachelor | 12 | 14% |
Student > Postgraduate | 9 | 10% |
Student > Ph. D. Student | 8 | 9% |
Researcher | 8 | 9% |
Other | 20 | 23% |
Unknown | 18 | 20% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 36 | 41% |
Agricultural and Biological Sciences | 7 | 8% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
Economics, Econometrics and Finance | 3 | 3% |
Other | 10 | 11% |
Unknown | 22 | 25% |