Title |
Image-Guided Radiotherapy for Cardiac Sparing in Patients with Left-Sided Breast Cancer
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Published in |
Frontiers in oncology, September 2014
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DOI | 10.3389/fonc.2014.00257 |
Pubmed ID | |
Authors |
Claire Lemanski, Juliette Thariat, Federico L. Ampil, Satya Bose, Jacqueline Vock, Rick Davis, Alexander Chi, Suresh Dutta, William Woods, Anand Desai, Juan Godinez, Ulf Karlsson, Melissa Mills, Nam Phong Nguyen, Vincent Vinh-Hung, The International Geriatric Radiotherapy Group |
Abstract |
Patients with left-sided breast cancer are at risk of cardiac toxicity because of cardiac irradiation during radiotherapy with the conventional 3-dimensional conformal radiotherapy technique. In addition, many patients may receive chemotherapy prior to radiation, which may damage the myocardium and may increase the potential for late cardiac complications. New radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) may decrease the risk of cardiac toxicity because of the steep dose gradient limiting the volume of the heart irradiated to a high dose. Image-guided radiotherapy (IGRT) is a new technique of IMRT delivery with daily imaging, which may further reduce excessive cardiac irradiation. Preliminary results of IGRT for cardiac sparing in patients with left-sided breast cancer are promising and need to be investigated in future prospective clinical studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 4 | 50% |
United Arab Emirates | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 50 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 20% |
Other | 6 | 12% |
Researcher | 4 | 8% |
Student > Bachelor | 3 | 6% |
Student > Doctoral Student | 3 | 6% |
Other | 10 | 20% |
Unknown | 14 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 32% |
Unspecified | 3 | 6% |
Physics and Astronomy | 3 | 6% |
Social Sciences | 2 | 4% |
Nursing and Health Professions | 2 | 4% |
Other | 7 | 14% |
Unknown | 17 | 34% |