Title |
Cytomegalovirus as a Novel Target for Immunotherapy of Glioblastoma Multiforme
|
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Published in |
Frontiers in oncology, October 2014
|
DOI | 10.3389/fonc.2014.00275 |
Pubmed ID | |
Authors |
Andrea Schuessler, David G. Walker, Rajiv Khanna |
Abstract |
Progress in the treatment of glioblastoma multiforme (GBM) over the last few decades has remained marginal and GBM is still universally fatal with short survival times after initial diagnosis. Much research is focused on finding new therapeutics for GBM and immune-based approaches have shown great promise. The detection of cytomegalovirus (CMV) antigens in malignant cells has suggested that treatment strategies based on immunological intervention, such as adoptive transfer of antiviral T cells or vaccination with viral epitopes, could be exploited as cancer therapy. Here, we review the rationale for using CMV as a therapeutic target and discuss the first clinical evidence for safety and efficacy of CMV-specific cellular immunotherapy for GBM. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Czechia | 1 | 2% |
Korea, Republic of | 1 | 2% |
Unknown | 62 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 22% |
Student > Bachelor | 14 | 22% |
Student > Ph. D. Student | 13 | 20% |
Other | 5 | 8% |
Student > Master | 4 | 6% |
Other | 7 | 11% |
Unknown | 8 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 32% |
Agricultural and Biological Sciences | 21 | 32% |
Biochemistry, Genetics and Molecular Biology | 5 | 8% |
Immunology and Microbiology | 2 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 6 | 9% |
Unknown | 8 | 12% |