Title |
A Single Case of Rosai–Dorfman Disease Marked by Pathologic Fractures, Kidney Failure, and Liver Cirrhosis Treated with Single-Agent Cladribine
|
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Published in |
Frontiers in oncology, October 2014
|
DOI | 10.3389/fonc.2014.00297 |
Pubmed ID | |
Authors |
Koji Sasaki, Naveen Pemmaraju, Jason R. Westin, Wei-Lien Wang, Joseph D. Khoury, Donald A. Podoloff, Bryan Moon, Naval Daver, Gautam Borthakur |
Abstract |
Rosai-Dorfman disease (RDD) is a proliferative histiocytic disorder of unknown etiology, which is characterized by sinus histiocytosis with massive lymphadenopathy (1). In most cases, RDD has a benign course and treatment is not necessary. However, severe cases of RDD require treatment, and the treatment strategy is determined on the basis of the severity of the disease or the extranodal involvement of vital organs. We report a single case of RDD with atypical presentation of persistent constitutional symptoms, progressing pathologic fractures, and end-organ dysfunction, including acute kidney failure and liver cirrhosis with esophageal varices. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 67% |
Switzerland | 1 | 11% |
Unknown | 2 | 22% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 44% |
Scientists | 4 | 44% |
Science communicators (journalists, bloggers, editors) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 4 | 20% |
Student > Bachelor | 2 | 10% |
Other | 1 | 5% |
Unspecified | 1 | 5% |
Professor | 1 | 5% |
Other | 4 | 20% |
Unknown | 7 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 50% |
Agricultural and Biological Sciences | 1 | 5% |
Unspecified | 1 | 5% |
Physics and Astronomy | 1 | 5% |
Immunology and Microbiology | 1 | 5% |
Other | 0 | 0% |
Unknown | 6 | 30% |