Title |
The Emerging Role of Exosomes in Epithelial–Mesenchymal-Transition in Cancer
|
---|---|
Published in |
Frontiers in oncology, December 2014
|
DOI | 10.3389/fonc.2014.00361 |
Pubmed ID | |
Authors |
Laura Jayne Vella |
Abstract |
Metastasis in cancer consists of multiple steps, including epithelial-mesenchymal-transition (EMT), which is characterized by the loss of epithelial-like characteristics and the gain of mesenchymal-like attributes including cell migration and invasion. It is clear that the tumor microenvironment can promote the metastatic cascade and that intercellular communication is necessary for this to occur. Exosomes are small membranous vesicles secreted by most cell types into the extracellular environment and they are important communicators in the tumor microenvironment. They promote angiogenesis, invasion, and proliferation in recipient cells to support tumor growth and a prometastatic phenotype. Although it is clear that exosomes contribute to cancer cell plasticity, experimental evidence to define exosome induced plasticity as EMT is only just coming to light. This review will discuss recent research on exosomal regulation of the EMT process in the tumor microenvironment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | <1% |
Chile | 1 | <1% |
France | 1 | <1% |
Korea, Republic of | 1 | <1% |
Mexico | 1 | <1% |
Belgium | 1 | <1% |
Unknown | 180 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 44 | 24% |
Researcher | 33 | 18% |
Student > Master | 30 | 16% |
Student > Bachelor | 19 | 10% |
Student > Doctoral Student | 12 | 6% |
Other | 21 | 11% |
Unknown | 27 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 56 | 30% |
Agricultural and Biological Sciences | 43 | 23% |
Medicine and Dentistry | 25 | 13% |
Engineering | 10 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
Other | 16 | 9% |
Unknown | 32 | 17% |