Title |
Molecular Heterogeneity in Glioblastoma: Potential Clinical Implications
|
---|---|
Published in |
Frontiers in oncology, March 2015
|
DOI | 10.3389/fonc.2015.00055 |
Pubmed ID | |
Authors |
Nicole Renee Parker, Peter Khong, Jonathon Fergus Parkinson, Viive Maarika Howell, Helen Ruth Wheeler |
Abstract |
Glioblastomas, (grade 4 astrocytomas), are aggressive primary brain tumors characterized by histopathological heterogeneity. High-resolution sequencing technologies have shown that these tumors also feature significant inter-tumoral molecular heterogeneity. Molecular subtyping of these tumors has revealed several predictive and prognostic biomarkers. However, intra-tumoral heterogeneity may undermine the use of single biopsy analysis for determining tumor genotype and has implications for potential targeted therapies. The clinical relevance and theories of tumoral molecular heterogeneity in glioblastoma are discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
Spain | 2 | <1% |
United Kingdom | 1 | <1% |
Brazil | 1 | <1% |
New Zealand | 1 | <1% |
Unknown | 253 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 57 | 22% |
Researcher | 33 | 13% |
Student > Master | 33 | 13% |
Student > Bachelor | 28 | 11% |
Student > Doctoral Student | 15 | 6% |
Other | 38 | 15% |
Unknown | 56 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 61 | 23% |
Medicine and Dentistry | 51 | 20% |
Agricultural and Biological Sciences | 38 | 15% |
Neuroscience | 14 | 5% |
Engineering | 10 | 4% |
Other | 29 | 11% |
Unknown | 57 | 22% |