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Molecular Heterogeneity in Glioblastoma: Potential Clinical Implications

Overview of attention for article published in Frontiers in oncology, March 2015
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Title
Molecular Heterogeneity in Glioblastoma: Potential Clinical Implications
Published in
Frontiers in oncology, March 2015
DOI 10.3389/fonc.2015.00055
Pubmed ID
Authors

Nicole Renee Parker, Peter Khong, Jonathon Fergus Parkinson, Viive Maarika Howell, Helen Ruth Wheeler

Abstract

Glioblastomas, (grade 4 astrocytomas), are aggressive primary brain tumors characterized by histopathological heterogeneity. High-resolution sequencing technologies have shown that these tumors also feature significant inter-tumoral molecular heterogeneity. Molecular subtyping of these tumors has revealed several predictive and prognostic biomarkers. However, intra-tumoral heterogeneity may undermine the use of single biopsy analysis for determining tumor genotype and has implications for potential targeted therapies. The clinical relevance and theories of tumoral molecular heterogeneity in glioblastoma are discussed.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 260 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 <1%
Spain 2 <1%
United Kingdom 1 <1%
Brazil 1 <1%
New Zealand 1 <1%
Unknown 253 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 57 22%
Researcher 33 13%
Student > Master 33 13%
Student > Bachelor 28 11%
Student > Doctoral Student 15 6%
Other 38 15%
Unknown 56 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 61 23%
Medicine and Dentistry 51 20%
Agricultural and Biological Sciences 38 15%
Neuroscience 14 5%
Engineering 10 4%
Other 29 11%
Unknown 57 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2015.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Frontiers in oncology
#15,918
of 22,416 outputs
Outputs of similar age
#233,343
of 271,799 outputs
Outputs of similar age from Frontiers in oncology
#75
of 92 outputs
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We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.