Title |
The Importance of Being Dead: Cell Death Mechanisms Assessment in Anti-Sarcoma Therapy
|
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Published in |
Frontiers in oncology, April 2015
|
DOI | 10.3389/fonc.2015.00082 |
Pubmed ID | |
Authors |
Santiago Rello-Varona, David Herrero-Martín, Laura Lagares-Tena, Roser López-Alemany, Núria Mulet-Margalef, Juan Huertas-Martínez, Silvia Garcia-Monclús, Xavier García del Muro, Cristina Muñoz-Pinedo, Oscar Martínez Tirado |
Abstract |
Cell death can occur through different mechanisms, defined by their nature and physiological implications. Correct assessment of cell death is crucial for cancer therapy success. Sarcomas are a large and diverse group of neoplasias from mesenchymal origin. Among cell death types, apoptosis is by far the most studied in sarcomas. Albeit very promising in other fields, regulated necrosis and other cell death circumstances (as so-called "autophagic cell death" or "mitotic catastrophe") have not been yet properly addressed in sarcomas. Cell death is usually quantified in sarcomas by unspecific assays and in most cases the precise sequence of events remains poorly characterized. In this review, our main objective is to put into context the most recent sarcoma cell death findings in the more general landscape of different cell death modalities. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 23% |
Spain | 3 | 23% |
Switzerland | 1 | 8% |
Unknown | 6 | 46% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 9 | 69% |
Science communicators (journalists, bloggers, editors) | 2 | 15% |
Practitioners (doctors, other healthcare professionals) | 1 | 8% |
Scientists | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 2% |
Poland | 1 | 2% |
Belgium | 1 | 2% |
Unknown | 40 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 23% |
Student > Bachelor | 9 | 21% |
Student > Master | 7 | 16% |
Researcher | 4 | 9% |
Student > Postgraduate | 4 | 9% |
Other | 7 | 16% |
Unknown | 2 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 19 | 44% |
Biochemistry, Genetics and Molecular Biology | 7 | 16% |
Medicine and Dentistry | 6 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 9% |
Chemistry | 2 | 5% |
Other | 2 | 5% |
Unknown | 3 | 7% |