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Immune Infiltration and Prostate Cancer

Overview of attention for article published in Frontiers in oncology, July 2015
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Title
Immune Infiltration and Prostate Cancer
Published in
Frontiers in oncology, July 2015
DOI 10.3389/fonc.2015.00128
Pubmed ID
Authors

Amy Strasner, Michael Karin

Abstract

It is becoming increasingly clear that inflammation influences prostate cancer (PCa) development and that immune cells are among the primary drivers of this effect. This information has launched numerous clinical trials testing immunotherapy drugs in PCa patients. The results of these studies are promising but have yet to generate a complete response. Importantly, the precise immune profile that determines clinical outcome remains unresolved. Individual immune cell types are divided into various functional subsets whose effects on tumor development may differ depending on their particular phenotype and functional status, which is often shaped by the tumor microenvironment. Thus, this review aims to examine the current knowledge regarding the role of inflammation and specific immune cell types in mediating PCa progression to assist in directing and optimizing immunotherapy targets, regimens, and responses and to uncover areas in which further research is needed. Finally, a summary of ongoing immunotherapy clinical trials in PCa is provided.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 197 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 1%
United States 2 1%
Germany 1 <1%
Unknown 192 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 30 15%
Student > Bachelor 29 15%
Student > Ph. D. Student 28 14%
Student > Master 22 11%
Other 15 8%
Other 37 19%
Unknown 36 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 46 23%
Medicine and Dentistry 42 21%
Agricultural and Biological Sciences 31 16%
Immunology and Microbiology 17 9%
Pharmacology, Toxicology and Pharmaceutical Science 4 2%
Other 16 8%
Unknown 41 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2015.
All research outputs
#19,944,994
of 25,374,647 outputs
Outputs from Frontiers in oncology
#9,319
of 22,416 outputs
Outputs of similar age
#188,386
of 276,134 outputs
Outputs of similar age from Frontiers in oncology
#43
of 71 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 22,416 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,134 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.