Title |
Melanoma: From Incurable Beast to a Curable Bet. The Success of Immunotherapy
|
---|---|
Published in |
Frontiers in oncology, July 2015
|
DOI | 10.3389/fonc.2015.00152 |
Pubmed ID | |
Authors |
Maria Libera Ascierto, Ignacio Melero, Paolo Antonio Ascierto |
Abstract |
After Coley's observation in 1891 of tumor regression in a patient who developed a postoperative infection, the field of immunotherapy is finally reborn. Avoiding immune destruction is now considered a hallmark of cancer, and the immunotherapy arena has exploded with the recent advances demonstrating an improvement in survival and a durability of response in patients with different cancer types, which translates into improved overall survival benefit. Here, we provide an overview of the main immune-oncology treatment strategies that, either alone or in combination, are undergoing clinical development. Namely, we will refer to those immunotherapeutic strategies that include adoptive transfer of ex vivo activated T cells, immunomodulatory monoclonal antibodies, and cancer vaccines. Our major focus will be to describe these approaches in melanoma, a cancer type transformed by immunotherapy into a potentially curable disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 50% |
United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 68 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 13% |
Student > Master | 9 | 13% |
Student > Bachelor | 9 | 13% |
Student > Ph. D. Student | 8 | 12% |
Other | 5 | 7% |
Other | 10 | 14% |
Unknown | 19 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 20% |
Agricultural and Biological Sciences | 14 | 20% |
Biochemistry, Genetics and Molecular Biology | 8 | 12% |
Immunology and Microbiology | 6 | 9% |
Social Sciences | 2 | 3% |
Other | 5 | 7% |
Unknown | 20 | 29% |