Title |
Factors Determining Colorectal Cancer: The Role of the Intestinal Microbiota
|
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Published in |
Frontiers in oncology, October 2015
|
DOI | 10.3389/fonc.2015.00220 |
Pubmed ID | |
Authors |
Esther Nistal, Nereida Fernández-Fernández, Santiago Vivas, José Luis Olcoz |
Abstract |
The gastrointestinal tract, in particular the colon, holds a complex community of microorganisms, which are essential for maintaining homeostasis. However, in recent years, many studies have implicated microbiota in the development of colorectal cancer (CRC), with this disease considered a major cause of death in the western world. The mechanisms underlying bacterial contribution in its development are complex and are not yet fully understood. However, there is increasing evidence showing a connection between intestinal microbiota and CRC. Intestinal microorganisms cause the onset and progression of CRC using different mechanisms, such as the induction of a chronic inflammation state, the biosynthesis of genotoxins that interfere with cell cycle regulation, the production of toxic metabolites, or heterocyclic amine activation of pro-diet carcinogenic compounds. Despite these advances, additional studies in humans and animal models will further decipher the relationship between microbiota and CRC, and aid in developing alternate therapies based on microbiota manipulation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Belgium | 1 | 7% |
Austria | 1 | 7% |
United States | 1 | 7% |
Australia | 1 | 7% |
Switzerland | 1 | 7% |
Unknown | 9 | 64% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 13 | 93% |
Scientists | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
Ghana | 1 | <1% |
Canada | 1 | <1% |
Unknown | 179 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 31 | 17% |
Student > Ph. D. Student | 22 | 12% |
Researcher | 21 | 12% |
Student > Bachelor | 17 | 9% |
Student > Postgraduate | 11 | 6% |
Other | 36 | 20% |
Unknown | 44 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 35 | 19% |
Agricultural and Biological Sciences | 29 | 16% |
Medicine and Dentistry | 27 | 15% |
Immunology and Microbiology | 17 | 9% |
Nursing and Health Professions | 4 | 2% |
Other | 21 | 12% |
Unknown | 49 | 27% |