Title |
The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling
|
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Published in |
Frontiers in oncology, October 2015
|
DOI | 10.3389/fonc.2015.00225 |
Pubmed ID | |
Authors |
Veronica Krenn, Andrea Musacchio |
Abstract |
Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player in chromosome segregation. As part of a macromolecular complex known as the chromosome passenger complex, Aurora B concentrates early during mitosis in the proximity of centromeres and kinetochores, the sites of attachment of chromosomes to spindle microtubules. There, it contributes to a number of processes that impart fidelity to cell division, including kinetochore stabilization, kinetochore-microtubule attachment, and the regulation of a surveillance mechanism named the spindle assembly checkpoint. In the regulation of these processes, Aurora B is the fulcrum of a remarkably complex network of interactions that feed back on its localization and activation state. In this review, we discuss the multiple roles of Aurora B during mitosis, focusing in particular on its role at centromeres and kinetochores. Many details of the network of interactions at these locations remain poorly understood, and we focus here on several crucial outstanding questions. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Switzerland | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
Netherlands | 1 | <1% |
United States | 1 | <1% |
Unknown | 364 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 111 | 30% |
Student > Master | 43 | 12% |
Student > Bachelor | 43 | 12% |
Researcher | 38 | 10% |
Student > Doctoral Student | 22 | 6% |
Other | 26 | 7% |
Unknown | 84 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 2% |
Chemistry | 5 | 1% |
Other | 17 | 5% |
Unknown | 89 | 24% |