Title |
Mutant p53: Multiple Mechanisms Define Biologic Activity in Cancer
|
---|---|
Published in |
Frontiers in oncology, November 2015
|
DOI | 10.3389/fonc.2015.00249 |
Pubmed ID | |
Authors |
Michael Paul Kim, Yun Zhang, Guillermina Lozano |
Abstract |
The functional importance of p53 as a tumor suppressor gene is evident through its pervasiveness in cancer biology. The p53 gene is the most commonly altered gene in human cancer; however, not all genetic alterations are biologically equivalent. The majority of alterations involve p53 missense mutations that result in the production of mutant p53 proteins. Such mutant p53 proteins lack normal p53 function and may concomitantly gain novel functions, often with deleterious effects. Here, we review characterized mechanisms of mutant p53 gain of function in various model systems. In addition, we review mutant p53 addiction as emerging evidence suggests that tumors may depend on sustained mutant p53 activity for continued growth. We also discuss the role of p53 in stromal elements and their contribution to tumor initiation and progression. Lastly, current genetic mouse models of mutant p53 in various organ systems are reviewed and their limitations discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | <1% |
Unknown | 111 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 23 | 21% |
Student > Master | 16 | 14% |
Student > Ph. D. Student | 14 | 13% |
Researcher | 13 | 12% |
Student > Doctoral Student | 7 | 6% |
Other | 12 | 11% |
Unknown | 27 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 43 | 38% |
Agricultural and Biological Sciences | 22 | 20% |
Medicine and Dentistry | 11 | 10% |
Chemistry | 2 | 2% |
Veterinary Science and Veterinary Medicine | 1 | <1% |
Other | 1 | <1% |
Unknown | 32 | 29% |