Title |
Glycosylated Notch and Cancer
|
---|---|
Published in |
Frontiers in oncology, February 2016
|
DOI | 10.3389/fonc.2016.00037 |
Pubmed ID | |
Authors |
Shanmugasundaram Pakkiriswami, Africa Couto, Usha Nagarajan, Marios Georgiou |
Abstract |
Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch and its ligands are repeatedly glycosylated by the addition of sugar moieties, such as O-fucose, O-glucose, or O-xylose, to bring about structural and functional changes. Disruption to glycosylation processes of Notch proteins result in developmental disorders and disease, including cancer. This review summarizes the importance and recent updates on the role of glycosylated Notch proteins in tumorigenesis and tumor metastasis. |
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Poland | 1 | 20% |
Switzerland | 1 | 20% |
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Demographic breakdown
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Scientists | 3 | 60% |
Members of the public | 2 | 40% |
Mendeley readers
Geographical breakdown
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Brazil | 1 | 2% |
Unknown | 42 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 27% |
Researcher | 9 | 20% |
Student > Bachelor | 6 | 13% |
Student > Master | 6 | 13% |
Student > Postgraduate | 2 | 4% |
Other | 4 | 9% |
Unknown | 6 | 13% |
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Business, Management and Accounting | 1 | 2% |
Other | 3 | 7% |
Unknown | 8 | 18% |